Tyrphostin AG-490 #14704
Inquiry Info. # 14704
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Product Information
Product Usage Information
Tyrphostin AG-490 is supplied as a lyophilized powder. For a 50 mM stock, reconstitute the 10 mg in 679.58 μl DMSO. Working concentrations and length of treatment can vary depending on the desired effect, but it is typically used at 10-100 μM for 1-24 hr.
Storage
Store lyophilized or in solution at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
Product Description
| Molecular Weight | 294.3 g/mol |
| Purity | >99% |
| Molecular Formula | C17H14N2O3 |
| CAS | 134036-52-5 |
| Solubility | Soluble in DMSO at 200mg/ml and EtOH at 16mg/ml. |
Background
Tyrphostin AG-490 is a membrane soluble protein tyrosine kinase inhibitor that primarily blocks Jak2 (IC50 = 10 μM) and Jak3 (IC50 = 20 μM) kinases (1,2). Research studies demonstrate that tyrphostin AG-490 inhibits proliferation and expansion of T cells (3). Unlike many other kinase inhibitors, tyrphostin AG-490 does not block a number of lymphocytic tyrosine kinases, such as Lck, Lyn, Btk, Syk, Jak1, Tyk2, or Src kinase (1,4). Additional studies indicate that tyrphostin AG-490 also selectively inhibits the EGFR (IC50 = 2 μM) and ErbB2 (IC50 = 13.5 μM) receptor tyrosine kinases (5).
Alternate Names
AG-490; AG490; Inhibitor; JAK; Mapk; Stat; Tyrophostin; Tyrphostin
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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