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  3. Lenalidomide

Lenalidomide #90543

    Product Information

    Product Usage Information

    Lenalidomide is supplied as a lyophilized powder. For a 15 mM stock, reconstitute 5 mg of powder in 1.29 mL of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Caution: Teratogenic. May cause harm to the unborn child. Avoid all contact with this product during pregnancy.

    Storage

    Store lyophilized at room temperature, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 259.2 g/mol
    Purity >98%
    Molecular Formula C13H13N3O3
    CAS 191732-72-6
    Solubility Soluble in DMSO at 30 mg/mL.

    Background

    The immunomodulatory drug Lenalidomide is one of a number of chemically modified analogs of the angiogenesis inhibitor, Thalidomide. Lenalidomide can act as an anti-tumor agent by suppressing angiogenesis and activating the immune system (1). Binding of Lenalidomide to Cereblon (CRBN), a substrate receptor for the CRL4 E3 ubiquitin ligase, causes selective ubiquitination and degradation of the zinc finger transcription factors Ikaros and Aiolos (2). A similar mechanism leads to the ubiquitination and targeted degradation of casein kinase 1α (CK1α) (3). Lenalidomide also downregulates SALL4, a zinc finger transcription factor that has been implicated in some human malformation syndromes, including Duane-radial ray syndrome (Okihiro syndrome) and Acro-renal-ocular syndrome (4). Lenalidomide (and other Thalidomide derivatives) can effectively treat multiple myeloma, mantle cell lymphoma, and non-Hodgkin follicular lymphoma (5-7) and can effectively induce remission in patients with myelodysplastic syndrome, either with or without chromosome 5q deletion (8).

    Alternate Names

    3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; CC-5013

    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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