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  3. A 83-01

A 83-01 #75073

    Product Information

    Product Usage Information

    A 83-01 is supplied as a lyophilized powder. For a 10 mM stock, reconstitute 5 mg of powder in 1.18 ml of DMSO. Working concentrations and length of treatment can vary depending on the desired effect.

    Storage

    Store lyophilized at -20ºC, desiccated. In lyophilized form, the chemical is stable for 24 months. Once in solution, store at -20ºC and use within 2 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    Product Description

    Molecular Weight 421.5 g/mol
    Purity >98%
    Molecular Formula C25H19N5S
    CAS 909910-43-6
    Solubility Soluble in DMSO at 20 mg/ml.

    Background

    A 83-01 is a potent and selective inhibitor of TGF-β type I receptor ALK5 kinase, activin type IB receptor ALK4, and nodal type I receptor ALK7 with an IC50 value of 12, 45, and 7.5 nM, respectively (1). This small molecule has also been shown to inhibit Smad2/3 phosphorylation along with TGF-β-induced growth inhibition and induction of Twist and Wnt3 (1,2). A 83-01 can be used to stabilize rat induced pluripotent stem cell (riPSC) cultures by inhibiting spontaneous differentiation and increasing the clonal expansion efficiency (3).

    限制使用

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