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  3. CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody #81945

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  • WB
  • IHC

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 55
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:200 - 1:800

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    For a carrier free (BSA and azide free) version of this product see product #34209.

    Protocol

    Specificity / Sensitivity

    CEACAM7 (E5Q6X) Rabbit Monoclonal Antibody recognizes endogenous levels of total CEACAM7 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val141 of human CEACAM7 protein.

    Background

    Carcinoembryonic antigen (CEA)-related cell adhesion molecule 7 (CEACAM7) is a homodomeric glycoprotein that is covalently linked to the plasma membrane via a GPI anchor and modulates cell adhesion via its N-terminal IgV domain (1). In normal human tissues, CEACAM7 expression is largely restricted to epithelial cells of the colon and pancreatic ducts (2). While some research studies have demonstrated that CEACAM7 expression is downregulated in human colorectal carcinomas, other studies have highlighted high expression levels in some pancreatic ductal adenocarcinomas (PDAC) (3-5). Given the restricted expression pattern in normal human tissues, CEACAM7 is positioned as an attractive immunotherapeutic target for PDAC (4).

    Alternate Names

    Carcinoembryonic antigen CGM2; carcinoembryonic antigen gene family member 2; carcinoembryonic antigen related cell adhesion molecule 7; Carcinoembryonic antigen-related cell adhesion molecule 7; CEA; CEA cell adhesion molecule 7; CEACAM7; CEAM7; CGM2

    Database Links

    UniProt ID: Q14002


    Entrez-Gene Id: 1087


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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