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CXCR4 (F1K2M) Rabbit Monoclonal Antibody (BSA and Azide Free)

CXCR4 (F1K2M) Rabbit Monoclonal Antibody (BSA and Azide Free) #35696

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Product Specifications

REACTIVITY	M
SENSITIVITY	Endogenous
MW (kDa)	30-50
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IHC-Immunohistochemistry

Species Cross-Reactivity Key:

M-Mouse

Product Information

Product Usage Information

This product is the carrier free version of product #66825. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

Formulation

Supplied in 1X PBS (10 mM Na₂HPO₄, 3 mM KCl, 2 mM KH₂PO₄, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

For standard formulation of this product see product #66825

Storage

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Specificity / Sensitivity

CXCR4 (F1K2M) Rabbit Monoclonal Antibody (BSA and Azide Free) recognizes endogenous levels of total CXCR4 protein.

Species Reactivity:

Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly187 of mouse CXCR4 protein.

Background

CXCR4 is a chemokine receptor that belongs to the G protein-coupled receptor family. It is activated by a small cytokine, CXCL12, also known as stromal cell derived factor 1 (SDF1) (1). The main function of CXCR4 is the mediation of the homing of progenitor cells in the bone marrow and their recruitment to sites of injury (2). More recently, CXCR4 has been studied as a potential therapeutic target in the context of autoimmune diseases (3), as well as cancer, as the receptor is involved in the regulation of migration, proliferation, and survival of cancer cells (4).

Alternate Names

b2b220C; b2b220Clo; C-X-C chemokine receptor type 4; CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C) receptor 4; chemokine receptor 4; Cmka; Cmkar4; CXC-R4; CXCR-4; Cxcr4; Fusin; LESTR; Leukocyte-derived seven transmembrane domain receptor; leukocyte-expressed seven-transmembrane-domain; OTTMUSP00000022912; PB-C; PB-CKR; PBSF/SDF-1; Pre-B-cell-derived chemokine receptor; Sdf; SDF-1 receptor; Sdf1r; Stromal cell-derived factor 1 receptor

Database Links

UniProt ID: P70658

Entrez-Gene Id: 12767

限制使用

除非 CST 的合法授书代表以书面形式书行明确同意，否书以下条款适用于 CST、其关书方或分书商提供的书品。任何书充本条款或与本条款不同的客书条款和条件，除非书 CST 的合法授书代表以书面形式书独接受，否书均被拒书，并且无效。

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For Research Use Only. Not for Use in Diagnostic Procedures.

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