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海报展示

Cell Signaling Technology 的科学家会定期在科学会议上展示海报。我们的研究是为信号转导通路分析和细胞生物学机制研究开发新技术。

我们调查研究的可移植文档格式 (PDF) 文件链接如下所示。某些 PDF 文件较大。每个文件的大小如下所列。

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改进的酪氨酸磷酸化、赖氨酸乙酰化和赖氨酸琥珀酰化肽的免疫亲和富集方法具有高灵敏度和特异性。
Barry M. Zee、Hayley J. Peckham、Alissa J. Nelson、Charles L. Farnsworth；Kathryn E. Abell、Jian Min Ren、Michael C. Palazzola、Kelly D. Peterson、Matthew P. Stokes
3.66 MB PDF
开发用于表征阿尔茨海默病鼠类模型中小胶质细胞激活状态的新型兔单克隆抗体
Arica Aiello、Rebecca Gray、Virginia E. Bain、Amrik Singh、Gregory Innocenti、Supriya Singh、Thorsten Wiederhold、Richard W. Cho
25.6 MB PDF
磷酸化蛋白质组学揭示 GITR 激动对炎症和调节性 T 细胞亚群的差异调节
Andrew Davis、Lori Cunningham、Matthew Stokes、Alssa Nelson、Kathryn Abell、Michael Lewis、Roy Scialdone、Than Bui、Emily Alonzo、Gordon Freeman、Sarah R Klein
3.55 MB PDF
一种用于显示 FFPE 组织中的羟脯氨酸的免疫组织化学工具
Antony Wood、Lauren Carr、Jessica Simendinger、Laura Vehring、Susan Kane、Katherine Crosby
56.2 MB PDF
疾病的表观遗传标记和机制分析：您的成功 CUT&RUN 实验指南
Fang Chen、Christopher R. Comeau、Jillian Mason、Carrie A. Brown 和 Christopher J. Fry
17.43 MB PDF
滑膜肉瘤中 SS18-SSX 融合蛋白特异性抗体的开发与表征
Curtis Desilets、Fang Chen、Christopher Comeau、Katrina Costa、Katherine Crosby、Michelle Ferrante、Christopher Grange、Maggie Patrikas、Matthew McBride、Esther Baranov、Jason Hornick、Cigall Kadoch
15.8 MB PDF
使用羟脯氨酸抗体可视化 FFPE 组织中的整体胶原
Lauren Carr、Jessica Simendinger、Laura Vehring、Susan Kane、Katherine Crosby
2.86 MB PDF
具有高灵敏度、特异性和稳定性的泛素化肽的改进免疫亲和富集方法
Joshua Nathan、Yiying Zhu、Alissa J. Nelson、Michael C. Palazzola、Kathryn E. Abell、Charles L. Farnsworth, Jian Min Ren, Matthew P. Stokes, Kimberly A. Lee
3 MB PDF
SignalScan™ LCMS/MS 靶向检测随 SARS-CoV-2 感染和治疗的变化的蛋白和磷酸化水平分析
Yiying Zhu, Alissa J. Nelson, Amrik Singh, Susan Kane, Hayley Peckham, Jian Min Ren, Claire Simpson, Joshua Nathan, Tyler Levy, Tomer M. Yaron, Jared Johnson, Robert Schwartz, Benjamin Nilsson-Payant, Tristan Jordan, Benjamin R. tenOever, Lewis C. Cantley, Sean A. Beausoleil, Kimberly A. Lee
3 MB PDF
研究癌症的标志：严格试剂验证对研究可重复性的重要性
Antony W. Wood、Susan Keezer、Gary Kasof、Jing Li、Jianxin Xie、Thorsten Wiederhold、Joshua Nathan 和 Samuel Jensen
6.22 MB PDF
使用微型质谱法定量肽
Spencer Chiang、Wenpeng Zhang、Kimberly Lee 和 Zheng Ouyang
4.13 MB PDF
使用陷阱型离子迁移谱和 PASEF 表征鉴定和定量磷酸肽位置异构物
Christopher M. Adams、Michael Krawitzky、Katherine Tran、Baozhen Shan、Zac Anderson、Charles Farsnsworth、Matthew P. Stokes、Kimberly Lee、Shourjo Ghose、Matthew Willetts 和 Gary Kruppa
0.43 MB PDF
使用陷阱型离子迁移率表征鉴定复杂细胞裂解物中的高灵敏度 PTM
Matthew Willetts、Shourjo Ghose、Gary Kruppa、Matthew Stokes、Charles Farnsworth 和 Kimberly Lee
0.26 MB PDF
使用新的抗生物素抗体及其应用来研究氧化还原信号，改善了生物素化肽富集和位点分配的可重复性
Meagan E. Olive、Yiying Zhu、Kimberly A. Lee、Samuel A. Myers、Namrata D. Udeshi 和 Steven A. Carr
0.97 MB PDF
用于从复杂混合物中捕获 KGG 修饰肽的自动 PTMScan® 免疫亲和富集
Lilian Phu、Shadie Nimri、Anne Baldwin、Nadia Martinez Martin、Chris Suh、Matthew P. Stokes 和 Donald S. Kirkpatrick
11.56 MB PDF
ABRF-sPRG 2018-2019：稳定同位素标记磷酸肽标准品的开发和表征鉴定
Anthony Herren、Brian Searle、Ryan Leib、Kimberly Lee、Bhavin Patel、David Hawke、Paul Stemmer、Alexandre Rosa Campos、Allis Chien 和 Antonius Koller
1.03 MB PDF
ABRF-sPRG 2017-2018：稳定同位素标记磷酸肽标准品的开发和表征鉴定
Anthony Herren、Brian Searle、Ryan Leib、Kimberly Lee、Bhavin Patel、David Hawke、Brett Phinney、Allis Chien 和 Antonius Koller
0.83 MB PDF
珠子辅助型质谱法 (BAMS)：一种用于多重生物标志物检测的可靠亲和捕获质谱法
Yiying Zhu、Matthew D. Fry、Alissa J. Nelson、Jianmin Ren、Vicky Yang、Michael C. Palazzola、Charles L. Farnsworth、Matthew P. Stokes、Kimberly A. Lee
1.46 MB PDF
用于分析丝氨酸/苏氨酸 O-糖基化修饰蛋白的新型兔单克隆抗体
Matthew D. Fry, Rami Najjar, Yiying Zhu, Jian Min Ren, Devin K. Schweppe, Steven P. Gygi, Matthew P. Stokes, Kimberly A. Lee
0.72 MB PDF
Quantitative Profiling of Post-Translational Modifications in E. coli
Charles L Farnsworth, Xiaoying Jia, Jian Min Ren, Kimberly Lee, Justin Tropp, Wayne Gatlin, Zach Norring
1.6 MB PDF
Novel antibody reagents for the characterization of Protein ADP-ribosylation
Alvin Lu, Rami Najjar, Mario Niepel, Matthew P Stokes
2.9 MB PDF
PD-1 blockade activates conventional CD4+ T cells and the innate immune response during glioblastoma eradication
Sarah Klein, Jennifer Ziello, Maria Speranza, Prafulla Gokhale, Paul Kirschmeier, Katherine Crosby, Gordon Freeman, David Reardon
2.2 MB PDF
Characterization of Immune Infiltrate and Checkpoint Protein Expression Patterns in Murine Syngeneic Tumors via Multiplex Immunohistochemistry
Jennifer Ziello, Sarah Klein, Katrina Costa, Katherine Crosby
1.3 MB PDF
Mass spectrometry-based profiling of lysine acetylation and arginine methylation for biomarker discovery in triple negative breast cancer
Alissa J. Schunter, Hongbo Gu, Jian Min Ren, Vicky Yang, Matthew P. Stokes
1.1 MB PDF
Multiplexed cellular signaling pathway profiling through targeted peptide immunoenrichment and quantitative analysis by LCMS
Kimberly A. Lee, Yiying Zhu, Jian Min Ren, Charles L. Farnsworth, Matthew P. Stokes
1.5 MB PDF
Co-expression and Frequency of Immune Checkpoint Proteins in the Tumor Microenvironment Analyzed via Multiplex Immunohistochemistry
Jennifer Ziello, Sarah Klein, Katherine Crosby
1.9 MB PDF
Development of a glycosylation-independent, IHC-validated recombinant Rabbit monoclonal antibody against the cancer stem cell marker CD133
Antony W Wood, Richard Cotta, Matthew Prokop, Jessica Simendinger
3.4 MB PDF
Multiplex IHC Detection of Immune Checkpoint Receptors in the Tumor Microenvironment
Jennifer Ziello, Sarah Klein, Emily Alonzo, Herbert Haack, Katherine Crosby
2.8 MB PDF
Targeting critical signaling nodes using multiplexed antibody based phosphopeptide enrichment with iMRM validation
Charles L Farnsworth, Yiying Zhu, Xiaoying Jia, Kimberly A Lee, Matthew P Stokes
2.2 MB PDF
Highly Multiplexed IHC Assays to Examine Immune Checkpoints and Biomarkers for Immunotherapy
Jennifer Ziello, Sarah Klein, Lauren Carr, Katherine Crosby, Emily Alonzo, Herbert Haack
8.3 MB PDF
The Use of Highly Validated Recombinant Monoclonal Antibodies to Analyze Histone Modifications and Transcription Factor Binding by ChIP-seq
Fang Chen, Yuichi Nishi, Dennis J. O'Rourke, Curtis D. Desilets, Christopher J. Fry
5.6 MB PDF
Efficient Enrichment of Endogenous SUMOylated Peptides from Alpha-lytic Protease Digest Using K-Ɛ-GG Remnant Immuno-affinity Purification
Hongbo Gu, Xiaoying Jia, Jianmin Ren, Elizabeth Komives, Matthew Stokes
3 MB PDF
Quantitative Profiling of Prokaryotic Post Translational Modifications
Charles L. Farnsworth, Xiaoying Jia, Jian Min Ren, Kimberly Lee, Jake Namaroff, Matthew P. Stokes
1.8 MB PDF
New Antibody Reagents to Study Stem Cell-Mediated Development and Regeneration of the Mammalian Intestinal Epithelium
Antony W. Wood, Richard Cotta, Katherine Crosby, Aparna Viswanathan, Christine Gagan, Jessica Simendinger
1.3 MB PDF
Global, Site Specific Identification and Quantification of Endogenous SUMO Modifications under Native Conditions
Hongbo Gu, Xiaoying Jia, Jian Min Ren, Elizabeth Komoves, Matthew P. Stokes
1.3 MB PDF
Sequential Immunoaffinity Purification of Post-Translationally Modified Peptides for Improved Enrichment Specificity
Matthew P. Stokes, Charles L. Farnsworth, Hongbo Gu, Xiaoying Jia, Kimberly A. Lee, Jian Min Ren, Vicky Yang
1.5 MB PDF
Development and Validation of a Novel EGF Receptor-Neutralizing (D1D4J) Monoclonal Antibody
Krystyna Zuberek Hincman, Christopher A. Manning, Michael Nelson, Michael Lewis, Roy Scialdone, Jaime Darce, Stephen Lutz, Evans John Burford, Herbert Haack, Matthew Silver
0.8 MB PDF
Proteomic Analysis Identifies Multi-Dimensional Deregulated Signaling Pathways in SCLC Lung Cancer
Klarisa Rikova, Ben Hall, Tyler Levy, Anthony Possemato, Mike Aguiar, Sean Beausoleil, Jian Min Ren, Kimberly Lee, Scott Lonning, Michael Comb
0.8 MB PDF
The Use of Highly Validated Rabbit Monoclonal Antibodies to Analyze Epigenetic Marks and Mechanisms in Disease
Christopher J. Fry, Curtis D. Desilets, Mieke Sprangers, Sarah L. Lambert, Lana Peckham, Jillian Mason, Dennis J. O’Rourke, Yuichi Nishi, Sayura Aoyagi.
3.9 MB PDF
Demonstration of Orthogonal Complementary Enrichment Methods for Enhanced Phosphopeptide Profiling of Drug-Treated Gastric Carcinoma Cells
Charles L. Farnsworth, Hongbo Gu, Xiaoying Jia, Jian Min Ren, Kimberly Lee, Jeffrey C. Silva.
7.6 MB PDF
An Improved Immunoaffinity Reagent for Quantitative Profiling of Lysine Acetylation
Jeffrey C. Silva, Ailan Guo, Anthony Couvillon, Rami Najjar, Daniel Mulhern, Kimberly A. Lee, Jian-min Ren, Xiaoying Jia, Hongbo Gu.
2.7 MB PDF
Profiling and Cross-Talk of Tyrosine Phosphorylation with Lysine Acetylation and Succinylation in Tyrosine Kinase Inhibitor Resistant Breast Cancer Cells
Hongbo Gu, Erik J. Soderblom, J. Will Thompson, Wenle Xia, Kimberly A. Lee, Jian-min Ren, Neil Spector, M. Arthur Moseley, Jeffrey C. Silva.
2.8 MB PDF
Automated Immunoaffinity-based Proteomic Methods for the Study of Post-translational Modification
Matthew P. Stokes, Jeffrey C. Silva, Steven Murphy, Jason Russell, Xiaoying Jia, Jian Min Ren, Kimberly Lee.
3.9 MB PDF
Epigenetic Changes Correlate with Loss of Pluripotency Marker Expression During Retinoic Acid-induced Differentiation of NTERA-2 Cells
Antony W. Wood, Susan Kane, Christopher J. Fry, Raffi Manoukian, Curtis D. Desilets
1.4 MB PDF
Highly Parallel Planar Surface Antibody Array-based Assay to Monitor Protein-protein Interactions
Jacob Knowles, Stephen Capodilupo, Richard Noring, Roberto Campos-González, Julio E. Herrera, Zev Gechtman
2.8 MB PDF
Mapping deregulated pathways downstream of RTKs in cell line models.
Klarisa Rikova, Benjamin Hall, Anthony Possemato, Keri Mroszczyk, Kimberly A. Lee, Jian Min Ren, Ailan Guo, Daniel Mulhern, Yi Wang, Sean A. Beausoleil, Michael J. Comb
2.8 MB PDF
Understanding of Differing Sensitivity in EML4-ALK NSCLC Patients to Crizotinib and Geldanamycin.
Klarisa Rikova, Benjamin Hall, Anthony Possemato, Keri Mroszczyk, Kimberly A. Lee, Joan MacNeill, Jian Min Ren, Ailan Guo, Daniel Mulhern, Yi Wang, Sean A. Beausoleil, Michael J. Comb
3.9 MB PDF
Proteomic Based Analysis of Ovarian Cancer Pathways.
Klarisa Rikova, Benjamin Hall, Tyler Levy, Caroline Keroack, Anthony Possemato, Kimberly A. Lee, Joan MacNeill, Jian Min Ren, Ailan Guo, Daniel Mulhern, Yi Wang, Sean A. Beausoleil, Scott Lonning, Michael J. Comb
1.2 MB PDF
Probing EGFR, HER2, and c-Met Protein-Protein Interactions Using an Antibody Array.
Jacob Knowles, Stephen Capodilupo, Richard Noring, Roberto Campos-González, Julio Herrera and Zev Gechtman
2.1 MB PDF
Motif Antibody Enrichment Enables the Identification of a Large Discrete and Complementary Set of Phosphorylation Sites.
Anthony Possemato; Mike Aguiar, Kim Lee, Steven P. Gygi, Sean A. Beausoleil
3.5 MB PDF
Quantitative Profiling of the Acetylome in Mouse Tissue using Lysine Acetylation Reagents in Immunoaffinity LC-MS/MS.
Hongbo Gu, Matthew P. Stokes, Ailan Guo, Kimberly Lee, Jian Min Ren, Xiaoying Jia, Vipin Suri, Jeffrey Silva
3.4 MB PDF
Network and Pathway Analysis of Post-translationally Modified Peptides Identified by Immunoaffinity-based Proteomics.
Jeffrey C. Silva, Stuart Tugendreich, Hongbo Gu, Charles L. Farnsworth, Kimberly A. Lee, Xiaoying Jia, Jian Min Ren, Matthew P. Stokes
6.9 MB PDF
Development and application of highly sensitive SIM and SRM-based phosphopeptide immunoassays using the Q Exactive™ mass spectrometer.
Kimberly A. Lee, Joan MacNeill, Jing Zhou, Jian Yu, Matthew P. Stokes, Jeffrey C. Silva, Ailan Guo, Michael J. Comb
4.4 MB PDF
Quantitative profiling of signaling pathways using immunoaffinity purification and LC-MS/MS.
Matthew P. Stokes, Jian Min Ren, Kimberly A. Lee, Xiaoying Jia, Jeffrey C. Silva
20.5 MB PDF
Quantitative Profiling of the Acetylome in Mouse Tissue using Lysine Acetylation Reagents in Immunoaffinity LC-MS/MS.
Bryon F. Ricketts, Hongbo Gu, Matthew P. Stokes, Ailan Guo, Kimberly Lee, Jian Min Ren, Xiaoying Jia, Vipin Suri, Jeffrey Silva
4.2 MB PDF
Monitoring the evolution of antigen-specific antibodies in circulation and their corresponding B cell clones in longitudinal immunization case studies through the use of NG-XMT™.
Jaime R. Darce, Stephen R. Lutz, Shuji Sato, Jason G. Beaudet, Michael Palazzola, Ivan Gregoretti, Sasha Tkachev, Sean A. Beausoleil, Lana Popova, Ravi K. Ramenani, Elizabeth Moreno, Xiaowu Zhang, James S. Wieler, Sandra M. Schieferl, Roberto D. Polakiewicz, and Wan Cheung Cheung
2.9 MB PDF
Highly Parallel Planar Surface Antibody Array-based Assay to Monitor Protein-protein Interactions.
Jacob Knowles, Stephen Capodilupo, Richard Noring, Roberto Campos-González, Julio E. Herrera, and Zev Gechtman
1.2 MB PDF
Proteomic Characterization of the Evolution of the Circulating Antibody Response to Hepatitis B Virus Vaccination.
Shuji Sato,, Sean A. Beausoleil,, Lana Popova, Jason G. Beaudet, Ravi K. Ramenani, Xiaowu Zhang, James S. Wieler, Albrecht Moritz, Sandra M. Schieferl, Wan Cheung Cheung, and Roberto D. Polakiewicz
3.4 MB PDF
Comprehensive Quantitative Profiling of the Mouse Kinome using Data-independent LC-MS-MS/MSALL with SWATH™ Acquisition.
Jeffrey C. Silva, Matthew P. Stokes, Charles L. Farnsworth, Xiaoying Jia, Christie Hunter
909 KB PDF
Quantitative Profiling of Signaling Pathways Using PTMScan® Direct.
Matthew P. Stokes, Jeffrey C. Silva, Charles L. Farnsworth, Xiaoying Jia, Roberto Polakiewicz, Michael J Comb
2.2 MB PDF
The Large-scale Analysis of Protein Expression in Human Ovarian Tumor Samples by LC-MS/MS/MS.
Anthony Possemato, Sean Beausoleil, Klarisa Rikova, Hong Ren, Kimberly Lee, Michael Comb
1.7 MB PDF
Multiplexing Kinase Substrate Motif Antibodies for Expanded Coverage of the Serine/Threonine Kinome.
Charles L. Farnsworth, Jeffrey C. Silva, Matthew P. Stokes, Hongbo Gu, Ailan Guo, Kimberly A. Lee, Jian-Min Ren, Xiaoying Jia, Roberto D. Polakiewicz, Michael J. Comb
717 KB PDF
Immunoaffinity Enrichment and Quantitative Profiling of Protein Phosphorylation, Methylation, and Acetylation in Receptor Tyrosine Kinase Pathway-addicted Cancer Cell Lines.
Klarisa Rikova, Ailan Guo, Kimberly A. Lee, Anthony Possemato, Yi Wang, Sean A. Beausoleil, Daniel E. Mulhern, Jian Min Ren, Michael J. Comb
2.5 MB PDF
A Proteomics Approach for the Identification and Cloning of Monoclonal Antibodies from Serum.
Wan Cheung (Gabriel) Cheung*, Sean A. Beausoleil*, Xiaowu Zhang, Shuji Sato, Sandra M. Schieferl, James S. Wieler, Jason G. Beaudet, Ravi K. Ramenani, Lana Popova, Michael J. Comb, John Rush, and Roberto D. Polakiewicz.
*这些作者对本作品的贡献同等。
1.4 MB PDF
Over-expression of EphB1 leads to Stat3 phosphorylation.
Danielle Swain, Richard Noring, Jake Knowles, Roberto Campos-González, Zev Gechtman
1.1 MB PDF
Rapid quantification of autophagy in cell-based assays.
Christopher A. Manning, Michael R. Nelson, Paul Wylie, Diana Caracino, Randall K. Wetzel
1.9 MB PDF
The use of a four-color multiplex antibody-based assay with laser-scanning high content screening to examine kinase inhibitor effects on cellular signaling.
Jessica A. Cherry, Paul Wylie, Christopher A. Manning, Diana Caracino, Randall K. Wetzel
596 KB PDF
PTMScan® Direct: Quantitative Profiling of Critical Nodes From Cellular Signaling Pathways.
Matthew P. Stokes, Jeffrey C. Silva, Charles L. Farnsworth, Xiaoying Jia, Albrecht Moritz, Ailan Guo, John Rush, Roberto Polakiewicz, Michael J. Comb
8.1 MB PDF
Mutation-Specific Antibodies for the Detection of EGFR Mutations in Non-Small-Cell Lung Cancer.
Jian Yu, Susan Kane, Daiqiang Li, Herbert Haack, Bradley Smith, Ting-Lei Gu, Massimo Loda, Xinmin Zhou, Michael J. Comb
1.6 MB PDF
Analysis of kinase inhibitors using a large array of signaling antibodies and high content screening.
Jessica A. Cherry, Corinne Michaud, Paul Wylie, Randall K. Wetzel
852 KB PDF
Evaluation of PTEN: Immunohistochemical Analysis of Tissues and Cells.
Angela Lightbown, Qingfu Zeng, Michael Lewis, Katherine Crosby, Bradley L. Smith
360 KB PDF
Detection of Genetic Abnormalities in Cancer Cells using Bio-Plex® Immuno-Assays.
Andrew Romano, Kathleen Rogers, Susan Kane, Jeff Lee, Whei Feng, Bradley L. Smith, Reggie Prioli
246 KB PDF
Phosphorylation Signatures Identify Tyrosine Kinases Activated in Lung Cancer.
Klarisa Rikova, Ailan Guo, Qingfu Zeng, Anthony Possemato, Herbert Haack, Julie Nardone, Kimberly Lee, Yu Li, Laura Sullivan, Joan MacNeill, Corey Bakalarski, Judit Villen, John Kornhauser, John Rush, Steven Gygi, Roberto Polakiewicz, Michael Comb
822 KB PDF
Rapid and Quantitative Cell-Based Immunoaffinity Kinase Assay in a 96-well Format.
Jin Yuan, Craig Thompson
569 KB PDF
The Detection of Phosphoproteins by Bio-Plex® Assays in Cell, Xenograft and Human Tumor Lysate.
Jeremy Fisher, Kathleen Rogers, Katherine Crosby, Andrew Romano, Bradley L. Smith, Reginaldo Prioli
512 KB PDF
PhosphoSite®: A Knowledge Base of Post-Translational Modifications and Their Role in Cell Signaling.
David Merberg, Roland Carel, Jon Kornhauser, Juan Munoz, Beth Murray, Julie Nardone, Ousama Shamma, Elzbieta Skrzypek, Bin Zhang, Peter Hornbeck
1.1 MB PDF
Phospho-Specific Rabbit Monoclonal Antibodies Validated for Immunohistochemistry.
Cynthia Shapiro, Angela Lightbown, Kathleen Rogers, Jessica Simendinger, Michael Lewis, Katherine Crosby
2.9 MB PDF
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