PTMScan® Direct Cell Cycle and DNA Damage Service 允许对相关 DNA 损伤和细胞周期控制通路内一组确定的蛋白质位点进行靶向筛选和定量分析，而且该组蛋白质位点对药物发现、生物标记物发现或诊断学发展至关重要。下表列出了可使用 PTMScan® Cell Cycle and DNA Damage Service 进行监测的蛋白质位点列表。
总而言之，PTMScan® Direct Cell Cycle and DNA Damage 服务提供了一种可定性识别和定量分析 263 种蛋白质的 168 个特有的磷酸化位点的稳健方法。
| 细胞周期和 DNA 损伤蛋白质位点 | |||
|---|---|---|---|
| 细胞周期和 DNA 损伤蛋白质位点 | |||
| 53BP1 | 53BP1 (Ser265) | α-tubulin | APE1 |
| ATM | ATM (Ser1981) | ATM (Ser1983) | ATR |
| ATR (Ser428) | ATRIP | AurA (Thr287) | AurA (Thr288) |
| AurA (Thr292) | AurB | AurB (Thr232) | AurB (Thr236) |
| AurB (Tyr239) | AurC (Thr198) | AurC (Thr202) | AurC (Tyr205) |
| β-Actin | BLM | BLM (Ser74) | BRCA2 (Thr77) |
| Bub3 | Bub3 (Ser135) | Bub3 (Thr133) | CBP |
| CCND1 (Thr286) | CCND1 (Thr288) | CCNE1 | CCNK iso3 |
| CCNL1 (Ser372) | CCNL1 (Ser374) | CCNL1 (Tyr376) | CCNT1 (Ser626) |
| CCNYL1 | CDC123 | Cdc16 | Cdc23 |
| Cdc25B | Cdc25C | Cdc25C (Ser191) | Cdc25C (Ser198) |
| Cdc27 | Cdc37 | Cdc42 | CDC45L |
| CDCA7 (Thr213) | CDK1 | CDK1 (Thr14) | CDK1 (Tyr15) |
| CDK1 (Tyr19) | CDK10 | CDK11 | CDK2 |
| CDK2 (Thr14) | CDK2 (Tyr15) | CDK3 | CDK3 (Thr14) |
| CDK3 (Tyr15) | CDK4 | CDK5 (Tyr15) | CDK6 |
| CDK7 | CDK8 | CHED (Ser1054) | CHED (Ser1065) |
| CHED (Ser1066) | CHED (Thr1056) | CHED (Thr1058) | Chk1 |
| Chk1 (Ser296) | Chk1 (Ser307) | Chk1 (Ser308) | Chk1 (Ser315) |
| Chk1 (Ser316) | Chk1 (Ser317) | Chk1 (Ser345) | Chk1 (Ser357) |
| Chk1 (Thr348) | Chk1 (Tyr314) | Chk2 | Chk2 (Ser379) |
| DDB1 | DNA-PK | DNA-PK (Ser3205) | ERK1 |
| ERK1 (Thr202) | ERK1 (Tyr204) | ERK2 | ERK2 (Thr185) |
| ERK2 (Tyr187) | ERK5 (Thr219) | ERK5 (Tyr221) | FANCB |
| FANCD2 | FANCI | GAPDH | H2AX |
| H2AX (Ser140) | H2AX (Thr137) | H3 | JNK1 (Thr183) |
| JNK1 (Tyr185) | JNK2 (Thr183) | JNK2 (Thr188) | JNK2 (Tyr185) |
| JNK3 (Thr221) | JNK3 (Tyr223) | Ku70 | Ku80 |
| LOC651610 | LOC731751 (Ser3204) | MCM2 | MCM3 |
| MCM4 | MCM5 | MCM6 | MCM7 |
| MKK3 (Ser253) | MKK4 (Ser257) | MLH1 | MRE11A |
| MSH2 (Ser717) | MSH6 (Ser309) | MST1 (Ser40) | MST1 (Ser43) |
| Myt1 (Ser40) | NBS1 | NPM1 (Ser125) | NUCKS |
| NUCKS (Ser14) | NUCKS (Ser181) | NUCKS (Ser19) | NuMA-1 |
| NuMA-1 (Ser1772) | NuMA-1 (Ser395) | NuMA-1 (Thr1776) | p300 |
| p21Cip1 | p21Cip1 (Ser130) | p27Kip1 | p27Kip1 (Ser175) |
| p27Kip1 (Ser178) | p27Kip1 (Ser183) | p27Kip1 (Thr170) | p27Kip1 (Thr187) |
| p38α (Ser61) | p38α (Thr175) | p38α (Thr180) | p38α (Tyr182) |
| p38δ (Thr180) | p38δ (Tyr182) | p38γ (Ser180) | p38γ (Thr183) |
| p38γ (Tyr185) | p53 (Ser392) | p70S6K (Ser243) | p70S6K (Thr248) |
| p70S6K (Thr250) | p70S6K (Thr252) | p70S6K (Thr256) | p70S6Kb (Ser219) |
| p70S6Kb (Ser356) | p70S6Kb (Thr226) | p70S6Kb (Thr228) | p70S6Kb (Thr232) |
| p90RSK | p90RSK (Ser221) | p90RSK (Thr225) | p90RSK (Tyr220) |
| PARP1 (Ser179) | PCNA | PCTAIRE1 (Tyr176) | PCTAIRE2 (Tyr203) |
| PITSLRE (Tyr449) | PITSLRE B (Tyr437) | PMS2 (Ser425) | POLA |
| POLD1 | POLD2 | PRC1 (Ser500) | PRC1 (Ser501) |
| PRC1 (Ser513) | PRC1 (Ser516) | PRC1 (Thr509) | PRC1 (Tyr511) |
| Profilin-1 | Profilin-2 | Rad17 | RAD21 |
| RAD21L1 | RAD23A | RAD23B | RAD54B |
| RAD54B (Ser867) | RAD54B (Ser869) | Rb | Rb (Ser773) |
| Rb (Ser780) | Rb (Ser788) | Rb (Ser794) | Rb (Ser795) |
| Rb (Ser807) | Rb (Ser811) | Rb (Ser816) | Rb (Thr774) |
| Rb (Thr778) | Rb (Thr821) | Rb (Thr823) | Rb (Thr826) |
| Rb (Tyr790) | Rb (Tyr805) | Rb (Tyr813) | RBBP4 |
| RBBP7 | RCC1 | RFA2 | RFC1 (Ser923) |
| RFC2 | RFC3 | RFC4 | RFC5 |
| RhoQ | RPA1 | RPA3 | RRas |
| RSK2 | RSK2 (Ser227) | RSK2 (Thr231) | RSK2 (Tyr226) |
| RSK3 | RSK4 | RSK4 (Ser232) | RSK4 (Thr236) |
| RSK4 (Tyr231) | Smad5 (Ser57) | Smad5 (Ser58) | Smc5 |
| Smc5 (Ser792) | Smc5 (Ser793) | SMG1 (Ser111) | SMG1 (Ser121) |
| SMG1L (Ser111) | SMG1L (Ser121) | tau (Ser713) | tau (Ser717) |
| tau (Ser721) | tau (Thr720) | tau (Tyr711) | TOP2A |
| TOP2B | TOPBP1 | XPG (Ser324) | XPG (Ser697) |
| XPG (Ser699) | XRCC1 | XRCC1 (Ser241) | ZNF828 (Ser405) |
| ZNF828 (Ser505) | ZNF828 (Ser507) | ZNF828 (Thr403) | |