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UPK3B (DBRRM3.66) Rabbit mAb #24696

Filter:
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype IgG
    Application Key:
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Immunohistochemistry (Paraffin) 1:800 - 1:3200

    Storage

    Supplied in a PBS-based buffer containing sodium azide as a preservative. Stable for 12 months when stored at 4°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    UPK3B (DBRRM3.66) Rabbit mAb recognizes endogenous levels of total UPK3B protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant human UPK3B protein.

    Background

    Uroplakins are a family of apical transmembrane proteins that form specialized plaques localized to the asymmetrical unit membrane (AUM), providing a permeability barrier in the urothelium (1). Urothelial plaques are composed of Uroplakin IIIB/UPK3B and at least four other uroplakins (UPK1A, UPK1B, UPK2, and UPK3) (2). UPK3B is expressed in urothelial carcinomas and other human cancers and has been shown to be useful as a biomarker in mesotheliomas (3,4).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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