Name: TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb
Price: 336.00 USD
Availability: InStock

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WB

Supporting Data

REACTIVITY	H Mk
SENSITIVITY	Endogenous
MW (kDa)	56
Source/Isotype	Mouse IgG3

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
Mk-Monkey

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb recognizes endogenous levels of total TRXR2/TXNRD2 protein.

Species Reactivity:

Human, Monkey

Source / Purification

Monoclonal antibody is produced by immunizing animals with a recombinant protein specific to the carboxy terminus of human TRXR2/TXNRD2 protein.

Background

Thioredoxin reductases are selenoproteins that are critical for maintaining cellular redox balance and eliminating reactive oxygen species (ROS) (1-4). There are three known mammalian thioredoxin reductases: TRXR1/TXNRD1 (cytosolic), TRXR2/TXNRD2 (mitochondrial), and TRXR3/TXNRD3 (testis-specific) (1). TRXR2 may function to protect against tumor necrosis factor-α (TNF-α)-mediated ROS generation (5). TRXR2 is critical for normal heart development and function (1,4). TRXR2 KO mice experience embryonic lethality, while mitochondrial dysfunction seen in heart-specific TRXR2 KO mice results in congestive heart failure (4). In humans, certain rare mutations in TRXR2 have been linked to dilated cardiomyopathy (1). A recent study in the EPIC-Heidelberg cohort shows that serum selenium levels, in concert with certain SNPs in TRXR2 and other selenoproteins, can influence prostate cancer risk (6).

Alternate Names

KIAA1652; Selenoprotein Z; SelZ; thioredoxin reductase 2; Thioredoxin reductase 2 mitochondrial; thioredoxin reductase 3; thioredoxin reductase beta; Thioredoxin reductase TR3; TR; TR-beta; TR3; TRXR2; TXNRD2

Database Links

UniProt ID: Q9NNW7

Entrez-Gene Id: 10587

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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TRXR2/TXNRD2 (3F2-E12-F10) Mouse mAb #12029