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  3. TACI/TNFRSF13B/CD267 (E3P6X) Rabbit mAb (BSA and Azide Free)
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

TACI/TNFRSF13B/CD267 (E3P6X) Rabbit mAb (BSA and Azide Free) #81309

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    Supporting Data

    REACTIVITY M
    SENSITIVITY Endogenous
    MW (kDa) 20-30
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IF-Immunofluorescence 
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • M-Mouse 

    Product Information

    Product Usage Information

    This product is the carrier free version of product #93005. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

    This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

    BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

    Formulation

    Supplied in 1X PBS (10 mM Na2HPO4, 3 mM KCl, 2 mM KH2PO4, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

    For standard formulation of this product see product #93005

    Storage

    Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

    Specificity / Sensitivity

    TACI/TNFRSF13B/CD267 (E3P6X) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total TACI/TNFRSF13B/CD267 protein. This antibody is predicted to recognize mulitple isoforms of TACI/TNFRSF13B/CD267.

    Species Reactivity:

    Mouse

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the amino terminus of mouse TACI/TNFRSF13B/CD267 protein.

    Background

    Transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI), also known as tumor necrosis factor receptor superfamily member 13B (TNFRSF13B) and cluster of differentiation 267 (CD267), is a single-pass type III membrane receptor that is highly expressed on the surface of mature innate-like B cells, such as marginal zone and B-1 B cells in mice, and memory B cells in humans (1-3). TACI/TNFRSF13B/CD267 is also expressed on the surface of activated T cells (4), while monocytes and dendritic cells express lower levels of TACI/TNFRSF13B/CD267 primarily intracellularly (5,6). TACI/TNFRSF13B/CD267 is the receptor for soluble ligands BAFF/TNFSF13B and APRIL/TNFSF13 (7,8). Upon ligation, TACI/TNFRSF13B/CD267 recruits tumor necrosis factor receptor–associated factor (TRAF) family members and calcium signal-modulating cyclophilin ligand (CAMLG) in order to activate NFAT, NF-κB, and AP-1 transcriptional programs (9-11). TACI/TNFRSF13B/CD267 is necessary for T cell-independent type II and type I responses (1,12), negative regulation of B cell and T follicular helper cell numbers (13,14), and promotion of class switch recombination in B cells (15). Mutations and aberrant regulation of TACI/TNFRSF13B/CD267 has been associated with cancer, autoimmune diseases, and immunodeficiency disorders (16-18). Multiple isoforms produced by alternative splicing have been identified.
    1. von Bülow, G.U. et al. (2000) Mamm Genome 11, 628-32.
    2. Mantchev, G.T. et al. (2007) J Immunol 179, 2282-8.
    3. Tsuji, S. et al. (2011) Blood 118, 5832-9.
    4. Wang, H. et al. (2001) Nat Immunol 2, 632-7.
    5. Chang, S.K. et al. (2006) Blood 108, 2687-94.
    6. Chang, S.K. et al. (2008) J Immunol 180, 7394-403.
    7. Wu, Y. et al. (2000) J Biol Chem 275, 35478-85.
    8. Yu, G. et al. (2000) Nat Immunol 1, 252-6.
    9. Hymowitz, S.G. et al. (2005) J Biol Chem 280, 7218-27.
    10. Xia, X.Z. et al. (2000) J Exp Med 192, 137-43.
    11. von Bülow, G.U. and Bram, R.J. (1997) Science 278, 138-41.
    12. Ozcan, E. et al. (2009) J Allergy Clin Immunol 123, 1277-86.e5.
    13. Seshasayee, D. et al. (2003) Immunity 18, 279-88.
    14. Ou, X. et al. (2012) Proc Natl Acad Sci U S A 109, 15401-6.
    15. He, B. et al. (2010) Nat Immunol 11, 836-45.
    16. Castigli, E. et al. (2005) Nat Genet 37, 829-34.
    17. Moura, R.A. et al. (2013) J Rheumatol 40, 1293-302.
    18. Abo-Elfadl, M.T. et al. (2020) Cytokine 125, 154790.

    Database Links

    UniProt ID: Q9ET35


    Entrez-Gene Id: 57916


    限制使用

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    For Research Use Only. Not For Use In Diagnostic Procedures.
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