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  2. Primary Antibodies /
  3. NRCAM Antibody

NRCAM Antibody #55284

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  • WB

    Supporting Data

    REACTIVITY H M R
    SENSITIVITY Endogenous
    MW (kDa) 140
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 
    • M-Mouse 
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody

    Protocol

    Specificity / Sensitivity

    NRCAM Antibody recognizes endogenous levels of NRCAM protein.

    Species Reactivity:

    Human, Mouse, Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human NRCAM protein. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    Neuronal Cell Adhesion Molecule, or NRCAM, belongs to the immunoglobulins Cell Adhesion Molecules (CAM's) superfamily (1). NRCAM, an ankyrin-binding protein, contributes to the neurite outgrowth by providing directional signaling during axonal cone growth (2, 3, 4). Additionally, it plays a role in mediating the interaction between axons and Schwann cells and contributes to the formation and maintenance of Nodes of Ranvier (5, 6, 7, 8). NRCAM also plays an important role in the establishment of dendritic spines in developing cortical neurons (9). NRCAM is expressed in non-neuronal cells, mostly in endothelial cells (10).

    Alternate Names

    ankyrin binding CAM; ankyrin binding cell adhesion molecule; bravo; MGC138845; MGC138846; Neuron-glia-CAM-related cell adhesion molecule; Neuronal Cell Adhesion Molecule; NgCAM; NrCAM; NrCAM protein

    Database Links

    UniProt ID: Q92823


    Entrez-Gene Id: 4897


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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