Name: SIGIRR (E5M2V) Rabbit Monoclonal Antibody
Price: 339.00 USD
Availability: InStock

Filter:

WB
IP

Product Specifications

REACTIVITY	H M R
SENSITIVITY	Endogenous
MW (kDa)	75
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting
IP-Immunoprecipitation

Species Cross-Reactivity Key:

H-Human
M-Mouse
R-Rat

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000
Immunoprecipitation	1:100

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

SIGIRR (E5M2V) Rabbit Monoclonal Antibody recognizes endogenous levels of total SIGIRR protein.

Species Reactivity:

Human, Mouse, Rat

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly391 of human SIGIRR protein.

Background

SIGIRR (Single Ig IL-1-related receptor), also known as IL-1R8, belongs to the IL-1 receptor family characterized by the presence of a common intracellular Toll-IL-1 resistance (TIR) domain and extracellular Ig-like domains (1-3). SIGIRR is widely expressed in several epithelial tissues such as liver, lung, and kidney, and in leukocytes including monocytes, T and B lymphocytes, dendritic cells, and natural killer (NK) cells. It negatively modulates the activation upon ligand binding of certain TIR-containing receptors including members of IL-1 receptor family and TLR family (4-6). Recently SIGIRR was identified as a crucial checkpoint receptor in NK cells and a potential therapeutic target in several pathological conditions (7,8).

Alternate Names

IL-1R8; MGC110992; SIGIR; SIGIRR; single Ig and TIR domain containing; Single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; Single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8

Database Links

UniProt ID: Q6IA17

Entrez-Gene Id: 59307

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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SIGIRR (E5M2V) Rabbit Monoclonal Antibody #32850