Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
RTP4 (F7F6V) Rabbit mAb #39418
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 28 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:200 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
RTP4 (F7F6V) Rabbit mAb recognizes endogenous levels of total RTP4 protein. This antibody detects a 55 kDa and an 80 kDa protein of unknown identity in some cell lines.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ile190 of human RTP4 protein.
Background
Receptor-transporting protein 4 (RTP4) is a member of the RTP family of receptor chaperone proteins (1-3). The RTP family targets class A G protein-coupled receptors (GPCRs), which can act as receptors for taste, odor, and opioids (1-3). RTP4 mediates the maturation and trafficking of a heteromer consisting of a μ-opioid receptor (MOR) and δ-opioid receptor (DOR) and affects pain perception (1,3). As part of the immune response, RTP4 may contribute to the suppression of type I IFN induction during the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway following pathogen infection, functioning as a negative regulator (1,6). Additionally, human RTP4 binds to viral RNA and targets the replication phase of viral infection in testing coronavirus family members, including SARS-CoV-2, and is associated with the reduction of nucleocapsid protein (5).
- Décaillot, F.M. et al. (2008) Proc Natl Acad Sci USA 105, 16045-50.
- Schoggins, J.W. et al. (2011) Nature 472, 481-5.
- Fujita, W. (2020) Front Cell Neurosci 14, 609362.
- Fujita, W. et al. (2022) Biomolecules 12, 1471. doi: 10.3390/biom12101471.
- Kaur, R. et al. (2023) mBio 14, e0109023.
- Fujita, W. and Kuroiwa, Y. (2024) Int J Mol Sci 25, 13676. doi: 10.3390/ijms252413676.
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