RPS4Y1 (F7V5G) Rabbit mAb #64468

Ribosomal protein S4, Y-linked 1 (RPS4Y1) is a structural constituent of the 40S small subunit of the cytoplasmic ribosome, the fundamental machinery orchestrating protein synthesis within eukaryotic cells. Integral to the ribosome's architecture, RPS4Y1 plays a crucial role in the proper assembly and stability of the 40S subunit, and contributes to the fidelity and efficiency of messenger RNA (mRNA) translation (1-3). The human genome harbors paralogous genes encoding ribosomal protein S4, including RPS4X located on the X chromosome, alongside RPS4Y1 and RPS4Y2 on the Y chromosome. Being a Y-linked gene, RPS4Y1 exhibits primary expression in male cells (1,4). Notably, haploinsufficiency of ribosomal protein genes, encompassing those residing on sex chromosomes, has been implicated in the pathogenesis of diverse developmental disorders (5). The somatic loss of the Y chromosome (LoY), observed in cells of aging males, has also been intriguingly documented in several tumor types, prompting speculation regarding the roles of RPS4Y1 and other Y-linked loci in the pathology of these malignancies (4-6). Certain studies have proposed a potential involvement of RPS4X and RPS4Y1 in Turner syndrome, a genetic condition affecting females characterized by a missing or structurally altered X chromosome. Moreover, aberrant regulation of RPS4Y1 expression has been noted in specific pathological states, such as preeclampsia, where it may influence trophoblast cell migration and invasion throughsignaling cascade modulation, including Stat3 (1,3). The Y-linked genomic location of RPS4Y1 and the potential for differential expression relative to its X-linked counterpart led to interest in RPS4Y1 as a potential marker for identifying male cells (6,7).