RASAL2 (D6K9L) Rabbit Monoclonal Antibody #82481

Small GTPases act as molecular switches, regulating processes such as cell migration, adhesion, proliferation, and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and inhibited by GTPase-activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP. RASAL2 was initially identified as a GAP for the small GTPase Ras and later shown to interact with the Rho-GEF ECT2 and regulate Rho activity in human astrocytoma cells (1). Researchers have implicated RASAL2 as a suppressor of migration and metastasis in human cancer (2) and have shown that RASAL2 downregulation promotes epithelial-mesenchymal transition and metastasis in ovarian (3) and lung cancer (4). Conversely, other research studies show that RASAL2 can be oncogenic in triple-negative breast cancer by activating Rac1 signaling (5).

Phosphorylation of RASAL2 at Ser89 has been identified in several phosphoproteomics studies, and this modification may be relevant in human breast and lung cancer (6,7).