Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Rab10 (D36C4) XP® Rabbit mAb (BSA and Azide Free) #57398
Filter:
- WB
- IF
Supporting Data
| REACTIVITY | H M R Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 23 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IF-Immunofluorescence
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
- Mk-Monkey
Product Information
Product Description
| MW (kDa) | 23 |
Product Usage Information
This product is the carrier free version of product #8127. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.
Formulation
Supplied in 1X PBS (10 mM Na
Storage
Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Specificity / Sensitivity
Rab10 (D36C4) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total Rab10 protein.
Species Reactivity:
Human, Mouse, Rat, Monkey
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly190 of human Rab10 protein.
Background
Rab10 is a member of the Ras superfamily of small Rab GTPases (1) that interacts with Mss4, myosin V (Va, Vb and Vc) and GDI as it helps mediate sorting among cellular endosomes (2-4). Mutation analysis and GFP-fusion protein expression of Rab10 in MDCK cells determined that Rab10 plays a regulatory role in membrane protein transport between early endosomes and basolateral compartments (5,6). Rab10 associates with the GLUT4 complex as a target for AS160 and is required for insulin-stimulated GLUT4 translocation in adipocytes (7,8).
- Chen, Y.T. et al. (1993) Proc Natl Acad Sci USA 90, 6508-12.
- Burton, J.L. et al. (1994) EMBO J 13, 5547-58.
- Roland, J.T. et al. (2009) J Biol Chem 284, 1213-23.
- Chen, Y. et al. (2009) Biochem J 422, 229-35.
- Schuck, S. et al. (2007) Traffic 8, 47-60.
- Babbey, C.M. et al. (2006) Mol Biol Cell 17, 3156-75.
- Sano, H. et al. (2007) Cell Metab 5, 293-303.
- Larance, M. et al. (2005) J Biol Chem 280, 37803-13.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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