Render Target: SSR
Render Timestamp: 2025-02-11T12:39:31.299Z
Commit: 1bba917eefc12d62e72a522121e2774ffbd0ee36
XML generation date: 2025-02-04 23:01:17.099
Product last modified at: 2025-02-06T13:45:14.478Z
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PDP - Template Name: Monoclonal Antibody
PDP - Template ID: *******c5e4b77
R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

PR3 (F7Q7M) Rabbit mAb #8094

Filter:
  • WB
  • IHC

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 27-40
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IHC-Immunohistochemistry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunohistochemistry (Paraffin) 1:100 - 1:400

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    PR3 (F7Q7M) Rabbit mAb recognizes endogenous levels of total PR3 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala112 of human PR3 protein.

    Background

    Proteinase 3 (PR3 or PRTN3), also known as myeloblastin, is a serine protease primarily expressed in neutrophils (1). PR3 can be localized to both azurophilic granules and the plasma membrane, where it serves as a target of antineutrophil cytoplasmic autoantibodies (ANCA) in the autoimmune condition granulomatosis with polyangiitis, formerly known as Wegener's granulomatosis (2). PR3 can degrade elastin, a component of the extracellular matrix, and activate platelets, dendritic cells, and endothelial cells by interacting with the proteinase-activated receptors (PARs), PAR-1 and PAR-2 (3-6). PR3 is also capable of processing inflammatory cytokines, including TNF-α, IL-1β, and IL-18 (7). PR3 has recently been shown to play a role in hematopoietic differentiation by participating in the cleavage of histone H3. Through its ability to modulate Stat3 to promote myeloid differentiation, it may serve as a therapeutic target in acute myeloid leukemia (7,8).
    For Research Use Only. Not For Use In Diagnostic Procedures.
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