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  3. OAS2 (E2G4K) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

OAS2 (E2G4K) Rabbit Monoclonal Antibody #24344

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  • IP

    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 70
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    OAS2 (E2G4K) Rabbit Monoclonal Antibody recognizes endogenous levels of total OAS2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala330 of human OAS2 protein.

    Background

    2’-5’-oligoadenylate synthetase 2 (OAS2) is an enzyme induced by type 1 interferon that plays a key role in the host antiviral innate immune response (1,2). The OAS family of proteins includes OAS1, OAS2, OAS3, and OASL in humans (3). OAS2 is activated by cytosolic dsRNA and its enzymatic activity generates the second messenger 2’-5’-linked oligoadenylate. These 2’-5’-linked oligoadenylates bind to the ribonuclease RNase L, which then degrades viral and cellular RNA in an effort to curb viral replication (1). Research studies have shown that components of the OAS-RNase L system, including OAS2, are highly upregulated in response to SARS-CoV-2 infection, suggesting a role for this antiviral pathway in the pathogenesis of SARS-CoV-2 (4,5).

    Alternate Names

    (2-5')oligo(A) synthase 2; (2-5')oligo(A) synthetase 2; (2'-5')oligo(A) synthetase 2; 2-5A synthase 2; 2-5A synthetase 2; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2'5' oligoadenylate synthetase 2; MGC78578; OAS2; p69 OAS / p71 OAS; p69OAS / p71OAS

    Database Links

    UniProt ID: P29728


    Entrez-Gene Id: 4939


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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