MYH7 (E3G8Q) Rabbit Monoclonal Antibody #64038

Myosin heavy chain 7 (MYH7), also known as β-myosin heavy chain, is a type I slow-twitch fiber expressed in muscle fibers as well as heart ventricles and is essential for muscle contraction (1). MYH7 is composed of a globular head domain at the N-terminus, a hinge region, and an α-helical coil-coil rod domain (2). MYH7 forms a hexameric complex with two MYH7, two myosin light chain 2 (MYL2), and two myosin light chain 3 (MYL3) (3). The myosin-binding sites on actin filaments become exposed by the binding of Ca+, which leads to actin-myosin junction formation and the ability to glide along the actin base. The complexes become detached in the presence of ATP, and the next cycle of contraction is initiated when ATPase activity of the head domain hydrolyzes ATP (4). Mutations in the MYH7 gene can lead to hypertrophic cardiomyopathy (HCM), dilated CM (DCM), and left ventricle non-compaction (LVNC) (5).