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MESH1/HDDC3 (E2U8P) Rabbit mAb

MESH1/HDDC3 (E2U8P) Rabbit mAb #64943

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Supporting Data

REACTIVITY	H M
SENSITIVITY	Endogenous
MW (kDa)	22
Source/Isotype	Rabbit IgG

Application Key:

WB-Western Blotting

Species Cross-Reactivity Key:

H-Human
M-Mouse

Product Information

Product Usage Information

Application	Dilution
Western Blotting	1:1000

Storage

Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

Protocol

Specificity / Sensitivity

MESH1/HDDC3 (E2U8P) Rabbit mAb recognizes endogenous levels of total MESH1/HDDC3 protein.

Species Reactivity:

Human, Mouse

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro36 of human MESH1/HDDC3 protein.

Background

MESH1 (Metazoan SpoT homolog 1), also known as HDDC3 (HD domain-containing protein 3), is an NADPH phosphatase in the cytosol. MESH1/HDDC3 is induced in stressed cells, depleting NADPH and stimulating ferroptosis (1). In addition, removal of MESH1/HDDC3 maintains NADPH levels in cells under stress conditions and therefore promotes ferroptotic cell survival (1). Furthermore, knockdown of MESH1/HDDC3 was shown to induce endoplasmic reticulum (ER) stress and integrative stress responses to facilitate cancer cell survival (2).

Alternate Names

(ppGpp)ase; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1; HD domain containing 3; HD domain-containing protein 3; HDDC3; MESH1; Metazoan SpoT homolog 1; MGC45386; Penta-phosphate guanosine-3'-pyrophosphohydrolase

Database Links

UniProt ID: Q8N4P3

Entrez-Gene Id: 374659

限制使用

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For Research Use Only. Not for Use in Diagnostic Procedures.

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