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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

M-Sec/TNFAIP2 (F7G3U) Rabbit mAb #68095

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  • WB
  • IP

    Supporting Data

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa) 73
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    • IP-Immunoprecipitation 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Description

    MW (kDa) 73

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000
    Immunoprecipitation 1:50

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    M-Sec/TNFAIP2 (F7G3U) Rabbit mAb recognizes endogenous levels of total M-Sec/TNFAIP2 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human M-Sec/TNFAIP2 protein.

    Background

    M-Sec, also known as tumor necrosis factor alpha-induced protein 2 (TNFAIP2), is a cytosolic protein required for the formation of tunneling nanotubes (TNTs), thin channels between cells that play a variety of functions, including transfer of RNA, organelles, and pathogens (1-3). By interacting with RalA, M-Sec/TNFAIP2 triggers polymerization of F-actin to form TNTs (4,5). M-Sec/TNFAIP2 expression can be induced by exposure to inflammatory cytokines and retinoic acid, and outside of disease contexts, the protein is mainly expressed in endothelial and immune cells (6,7). Upregulation of M-Sec/TNFAIP2 has been reported in several types of cancer. It contributes to metastasis and angiogenesis, and it may serve as a biomarker and prognostic marker in a subset of cancers, including acute myeloid leukemia and triple-negative breast cancer (8-10).
    For Research Use Only. Not for Use in Diagnostic Procedures.
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