Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
M-Sec/TNFAIP2 (F7G3U) Rabbit mAb #68095
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 73 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
| MW (kDa) | 73 |
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
M-Sec/TNFAIP2 (F7G3U) Rabbit mAb recognizes endogenous levels of total M-Sec/TNFAIP2 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human M-Sec/TNFAIP2 protein.
Background
M-Sec, also known as tumor necrosis factor alpha-induced protein 2 (TNFAIP2), is a cytosolic protein required for the formation of tunneling nanotubes (TNTs), thin channels between cells that play a variety of functions, including transfer of RNA, organelles, and pathogens (1-3). By interacting with RalA, M-Sec/TNFAIP2 triggers polymerization of F-actin to form TNTs (4,5). M-Sec/TNFAIP2 expression can be induced by exposure to inflammatory cytokines and retinoic acid, and outside of disease contexts, the protein is mainly expressed in endothelial and immune cells (6,7). Upregulation of M-Sec/TNFAIP2 has been reported in several types of cancer. It contributes to metastasis and angiogenesis, and it may serve as a biomarker and prognostic marker in a subset of cancers, including acute myeloid leukemia and triple-negative breast cancer (8-10).
- Ohno, H. et al. (2010) Commun Integr Biol 3, 231-3.
- Zurzolo, C. (2021) Curr Opin Cell Biol 71, 139-147.
- Guan, F. et al. (2024) J Exp Clin Cancer Res 43, 147.
- Hase, K. et al. (2009) Nat Cell Biol 11, 1427-32.
- Kimura, S. et al. (2016) Sci Rep 6, 33548.
- Rusiniak, M.E. et al. (2000) Cancer Res 60, 1824-9.
- Jia, L. et al. (2018) J Cell Mol Med 22, 5188-5195.
- Xu, T. et al. (2025) Cell Commun Signal 23, 83.
- Ren, W. et al. (2024) Cell Death Dis 15, 821.
- Lin, M.S. et al. (2022) BMC Cancer 22, 1068.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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