LRSAM1 Antibody #14400
Inquiry Info. # 14400
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Supporting Data
| REACTIVITY | H Mk |
| SENSITIVITY | Endogenous |
| MW (kDa) | 84 |
| SOURCE | Rabbit |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- Mk-Monkey
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
LRSAM1 Antibody recognizes endogenous levels of total LRSAM1 protein.
Species Reactivity:
Human, Monkey
Source / Purification
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro143 of human LRSAM1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background
Leucine-rich repeat and sterile alpha motif-containing protein 1 (LRSAM1, hTAL1) is a multi-domain-containing E3 ubiquitin-ligase involved in the regulation of cell adhesion. The LSRAM1 protein contains amino-terminal leucine-rich repeats (LRR), an ezrin-radixin-moesin (ERM) domain, a coiled-coil region, a sterile alpha motif (SAM) domain, and a carboxy-terminal RING finger domain. Research studies demonstrate that LRSAM1 participates in the endosomal sorting of proteins by regulating the ubiquitination of Tsg101, a component of the ESCRT-I endosomal sorting complex (1). LSRAM1 ubiquitin ligase activity plays a critical role in promoting the ubiquitin-dependent autophagic clearance of pathogenic bacteria (2). Mutations in the corresponding LRSAM1 gene can contribute to a form of Charcot-Marie-Tooth (CMT2P) disease that is characterized by peripheral nervous system axonal neuropathy (3,4).
Alternate Names
E3 Ligases; E3 Ubiquitin Ligases; hTAL; LRSAM-1; LRSAM1; TAL; Ubiquitylation'
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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