Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Kv1.3/KCNA3 (F2R6N) Rabbit mAb #63168
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 60-80 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Description
| MW (kDa) | 60-80 |
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Kv1.3/KCNA3 (F2R6N) Rabbit mAb recognizes endogenous levels of total Kv1.3/KCNA3 protein.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Kv1.3/KCNA3 protein.
Background
Potassium voltage-gated channel subfamily A member 3, known as Kv1.3 or KCNA3, is a transmembrane protein that regulates potassium flux at the plasma and inner mitochondrial membranes (1,2). Kv1.3 has been implicated in Parkinson's disease (PD), as its expression is upregulated in postmortem human PD brains and mouse models of PD (3). Increased Kv1.3 activity in microglia is also linked to neuroinflammation and neuronal loss (3-5). On neutrophils, Kv1.3 is essential for recruitment to sites of acute inflammation, as it mediates calcium signaling required for migration (6). Kv1.3 is also important in the context of T cell activation, which also relies on calcium signaling; inhibition of Kv1.3 impedes T cell activation (7-9).
- Grissmer, S. et al. (1990) Proc Natl Acad Sci USA 87, 9411-5.
- Szabó, I. et al. (2008) Proc Natl Acad Sci USA 105, 14861-6.
- Sarkar, S. et al. (2020) J Clin Invest 130, 4195-4212.
- Maezawa, I. et al. (2018) Brain 141, 596-612.
- Ramesha, S. et al. (2021) Proc Natl Acad Sci USA 118, e2013545118.
- Immler, R. et al. (2022) Cardiovasc Res 118, 1289-1302.
- Lin, C.S. et al. (1993) J Exp Med 177, 637-45.
- Schmitz, A. et al. (2005) Mol Pharmacol 68, 1254-70.
- Fung-Leung, W.P. et al. (2017) PLoS One 12, e0170102.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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