Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
IL-1R1 (F6I2P) Rabbit mAb #39379
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 70-90 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
IL-1R1 (F6I2P) Rabbit mAb recognizes endogenous levels of total IL-1R1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human IL-1R1 protein.
Background
Interleukin-1 receptor type 1 (IL-1R1) is a transmembrane protein in the interleukin-1 (IL-1) protein family (1-3). IL-1R1 is the receptor for IL-1, which plays a central role in inflammatory responses (1-3). The IL-1 signaling cascade is initiated by the binding of interleukin-1 alpha (IL-1α) or interleukin-1 beta (IL-1β) to IL-1R1, which recruits the IL-1 receptor accessory protein (IL-1RAP) to form a receptor complex, leading to downstream expression of proinflammatory cytokines and chemokines (1-4). The IL-1 receptor antagonist (IL-1Ra) competes with IL-1α and IL-1β to bind IL-1R1, acting as an inhibitor of the IL-1 signaling pathway (4). Aberrant activation of the IL-1 pathway is associated with multiple disorders, such as rheumatoid arthritis, degenerative diseases, cardiovascular disorders, and cancer (4).
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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KARPAS cell line source: Dr. Abraham Karpas at the University of Cambridge.
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