Hendra henipavirus Nucleocapsid (F5N9K) Rabbit mAb #32952

Hendra virus (HeV) is a highly pathogenic zoonotic paramyxovirus belonging to the Henipavirus genus. It possesses a non-segmented, negative-sense single-stranded RNA genome which is tightly encapsidated by the nucleocapsid (N) protein to form a helical ribonucleoprotein (RNP) complex, the fundamental unit for viral RNA synthesis and genome protection (1). The N protein is a major structural component of the virus and a key player in its replication cycle. The primary function of the HeV N protein is the encapsidation of the viral genomic and antigenomic RNA. Encapsidation is essential for genome protection, template assembly for RNA synthesis, and nucleocapsid assembly. It also interacts with other viral proteins, such as the viral phosphoprotein (P), which acts as a chaperone for newly synthesized N protein subunits (2). Understanding the structure and function of the Hendra henipavirus N protein is critical for developing targeted antiviral therapies against this and other highly pathogenic viruses in the Paramyxoviridae family (3).