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  3. FBXL10 (D3T8J) Rabbit Monoclonal Antibody
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Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.

FBXL10 (D3T8J) Rabbit Monoclonal Antibody #44570

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  • WB

    Product Specifications

    REACTIVITY H
    SENSITIVITY Transfected Only
    MW (kDa) 180
    Source/Isotype Rabbit IgG
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.

    Protocol

    Specificity / Sensitivity

    FBXL10 (D3T8J) Rabbit Monoclonal Antibody recognizes transfected levels of total FBXL10 protein.

    Species Reactivity:

    Human

    Source / Purification

    Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the human FBXL10 protein.

    Background

    F-box and leucine-rich repeat protein 10 (FBXL10), also known as lysine-specific demethylase 2B (KDM2B) and JmjC domain-containing histone demethylation protein 1B (JHDM1B), is a lysine-specific histone demethylase protein that demethylates Lys4 and Lys36 of histone H3 (1,2). FBXL10 contains a zinc finger-CxxC5 DNA binding domain that binds to un-methylated CpG dinucleotides and has been shown to function as part of a non-canonical polycomb repressor complex (PRC1) that is associated with repression of developmentally regulated genes (3-5). In embryonic stem cells, FBXL10 is critical for targeting PRC1 to CpG islands and regulating gene expression during differentiation. In addition, FBXL10 is over-expressed in various cancers where it functions to induce cell proliferation and repress senescence through repression of the p15Ink4b gene locus (6-8). High expression of FBXL10 in pancreatic ductal adenocarcinoma is associated with metastasis, while high expression in acute myeloid leukemia is associated with increased proliferation and self-renewal of leukemic stem cells (6-8).

    Alternate Names

    [Histone-H3]-lysine-36 demethylase 1B; CXXC-type zinc finger protein 2; CXXC2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; FBL10; FBXL10; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; JHDM1B; JmjC domain-containing histone demethylation protein 1B; jumonji C domain-containing histone demethylase 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; KDM2B; lysine (K)-specific demethylase 2B; lysine demethylase 2B; Lysine-specific demethylase 2B; NDY1; PCCX2; protein containing CXXC domain 2; Protein JEMMA; Protein-containing CXXC domain 2

    Database Links

    UniProt ID: Q8NHM5


    Entrez-Gene Id: 84678


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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