Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
FATP1/SLC27A1 (F1Y1E) Rabbit mAb #78571
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 65 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
FATP1/SLC27A1 (F1Y1E) Rabbit mAb recognizes endogenous levels of total FATP1/SLC27A1 protein. This antibody does not cross-react with FATP2/SLC27A2 or FATP4/SLC27A4 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro210 of human FATP1/SLC27A1 protein.
Background
Long-chain fatty acid transport protein 1 (FATP1), also known as solute carrier family 27 member 1 (SLC27A1), promotes the uptake of long-chain fatty acids (LCFAs) by cells (1,2). FATP1/SLC27A1 is expressed in several insulin-sensitive tissues, such as adipose tissue and skeletal muscle. Studies on FATP1/SLC27A1 knockout mice show that FATP1/SLC27A1 is critical for insulin-induced LCFA uptake by adipocytes and skeletal muscle. In addition, FATP1/SLC27A1 is implicated in diet-induced obesity (2). Moreover, a small interfering RNA screen on primary human keratinocytes identified FATP1/SLC27A1 and ELOVL1, which encodes elongation of very long-chain fatty acids protein 1, to be involved in epidermal differentiation. FATP1/SLC27A1 knockdown led to induced keratinocyte differentiation (3).
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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