COL7A1 (F4Q8A) Rabbit Monoclonal Antibody #81703

Type VII collagen is a collagen family protein encoded by the COL7A1 gene. Collagen VII is formed by intertwining three COL7A1 chains to function as an anchoring fibril (1). The anchoring fibril is localized in the basement membrane and crucial for dermal-epidermal basement membrane adhesion through the interaction of the N-terminal NC1 domain of COL7A1 with collagen IV, laminin 332, and collagen I (2-5). Mutations of COL7A1 prevent type VII collagen secretion or interaction with other ECM molecules, lead to anchoring fibril deficiencies in the dermal-epidermal basement membrane, and result in skin blistering (Dystrophic Epidermolysis Bullosa) and poor wound healing (6-8). Type VII collagen deficiency also results in the oncogenesis of cutaneous squamous cell carcinoma through increasing TGF-β signaling and abnormal angiogenesis (9,10).