CD42b (F5I6V) Rabbit mAb #81165

The glycoprotein Ib-V-IX (GPIb-V-IX) complex is a platelet receptor that plays a crucial role in hemostasis and general platelet function (1). During vessel injury, multimeric von Willebrand factor (VWF) protein interacts with the GPIb-V-IX receptor expressed on circulating platelets, resulting in platelet activation, aggregation, and blood clot formation (2). GPIb-V-IX is composed of four individual protein subunits: CD42b (GPIbα), CD42c (GPIbβ), CD42d (GPV), and CD42a (GPIX) (3). CD42b, also known as GPIbα and encoded by the GP1BA gene, is the largest subunit and contains the binding domain for GPIb-V-IX ligands VWF and thrombin (3). Mutations in the GP1BA gene are often associated with platelet bleeding disorders, such as Bernard-Soulier syndrome (BSS) and platelet-type von Willebrand disease (PT-VWD) (4,5). Autoimmunity against CD42b can result in another bleeding disorder known as primary immune thrombocytopenia (ITP); interestingly, T cells engineered with CD42b chimeric autoantibody receptor (CAAR) have shown promise in specifically targeting autoreactive B cells and treating this disease (6).