CD1A (MTB1) Mouse mAb #90916
Filter:
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | |
| Source/Isotype | Mouse IgG1 kappa |
Application Key:
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| IHC Leica Bond | 1:50 |
| Immunohistochemistry (Paraffin) | 1:50 |
Storage
Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
CD1A (MTB1) Mouse mAb recognizes endogenous levels of CD1A protein. Non-specific staining was observed in testis by immunohistochemistry.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant fusion protein corresponding to the full external domain of human CD1A protein.
Background
CD1A is a type 1 cell surface transmembrane glycoprotein structurally similar to MHC Class 1 that is expressed in association with β2-microglobulin (1). CD1A is a member of the CD1 family and has been shown to mediate the presentation of primary lipid and glycolipid antigens to T cell lymphocytes for recognition (1,2). It is expressed by Langerhans’ cells, cortical double positive and single positive thymocytes, and by interdigitating dendritic cells (1). CD1A has been shown to identify T cell development (3).
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For Research Use Only. Not For Use In Diagnostic Procedures.
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