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  3. C/EBP beta Antibody

C/EBP beta Antibody #3082

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  • WB

    Product Specifications

    REACTIVITY R
    SENSITIVITY Endogenous
    MW (kDa) 34 (LAP), 38 (Full Length)
    SOURCE Rabbit
    Application Key:
    • WB-Western Blotting 
    Species Cross-Reactivity Key:
    • R-Rat 

    Product Information

    Product Usage Information

    Application Dilution
    Western Blotting 1:1000

    Storage

    Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.

    实验步骤

    Specificity / Sensitivity

    C/EBP beta Antibody detects endogenous levels of rat C/EBPbeta protein. This antibody does not cross-react with other C/EBP family members such as C/EBPalpha, -delta, -gamma, -epsilon or -zeta. This antibody also does not recognize the p20 LIP rat C/EBPbeta isoform.

    Species Reactivity:

    Rat

    Source / Purification

    Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser105 of rat C/EBPbeta. Antibodies are purified by protein A and peptide affinity chromatography.

    Background

    CCAAT/enhancer-binding proteins (C/EBPs) are a family of transcription factors critical for cellular differentiation, terminal functions, and inflammatory response (1). Six members of the family have been characterized (C/EBPα, -β, -γ, -δ, -ε, and -ζ) and are distributed in a variety of tissues (1). There are two forms of C/EBPβ, the 38 kDa liver activating protein (LAP) and the 20 kDa liver inhibitory protein (LIP) which may be products of alternative translation. The 38 kDa LAP protein is a transcriptional activator while LIP may act as an inhibitor of C/EBPβ transcriptional activity (2). Phosphorylation of C/EBPβ at distinct sites stimulates its transcriptional activity (3-5). Phosphorylation at serine 105 of rat C/EBPβ, a unique site only present in the rat sequence, seems essential for rat C/EBPβ activation (6).

    Alternate Names

    C/EBP beta; C/EBP-beta; C/EBP-related protein 2; CCAAT/enhancer binding protein (C/EBP), beta; CCAAT/enhancer-binding protein beta; Cebpb; Crp2; IL-6DBP; Il6dbp; Interleukin-6-dependent-binding protein; LAP; Liver activating protein (LAP also NF-IL6 nuclear factor-IL6 previously designated TCF5); Liver activating protein (LAP, also NF-IL6, nuclear factor-IL6, previously designated TCF5); liver activating protein (LAP); Liver-enriched transcriptional activator; NF-IL6; nuclear factor-IL6; SF-B; Sfb; Silencer factor B; TCF5

    Database Links

    UniProt ID: P21272


    Entrez-Gene Id: 24253


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
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