Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
AUTS2 (F3U1I) Rabbit mAb #40506
Filter:
- WB
- IP
Supporting Data
| REACTIVITY | H M |
| SENSITIVITY | Endogenous |
| MW (kDa) | 180, 80-90 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IP-Immunoprecipitation
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
| Immunoprecipitation | 1:50 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
AUTS2 (F3U1I) Rabbit mAb recognizes endogenous levels of total AUTS2 protein, including both long and short isoforms.
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly776 of human AUTS2 protein.
Background
Autism susceptibility candidate 2 (AUTS2) is a transcriptional activator protein that was first identified in a pair of homozygous twins with autism spectrum disorder (ASD) (1). AUTS2 associates with the non-canonical polycomb repressive complex 1 (ncPRC1) and recruits the histone acetyltransferase p300 to activate gene expression (2). AUTS2 is primarily expressed in early developing brain tissue and contributes to neuronal differentiation (3). AUTS2 is expressed as either a full-length “long” protein isoform or a “short” isoform lacking the N-terminus due to an alternative transcription start site (4). The exact biological differences between the two isoforms are not fully understood, but they may target distinct genes during differentiation (5). Defects in the AUTS2 gene result in AUTS2 syndrome, a neurodevelopmental disorder characterized by intellectual disability, microcephaly, and autistic traits (6-8).
- Sultana, R. et al. (2002) Genomics 80, 129-34.
- Gao, Z. et al. (2014) Nature 516, 349-54.
- Biel, A. et al. (2022) Front Mol Neurosci 15, 858582.
- Yamashiro, K. et al. (2020) iScience 23, 101820.
- Monderer-Rothkoff, G. et al. (2021) Mol Psychiatry 26, 666-681.
- Beunders, G. et al. (2013) Am J Hum Genet 92, 210-20.
- Beunders, G. et al. (2016) J Med Genet 53, 523-32.
- Sanchez-Jimeno, C. et al. (2021) Genes (Basel) 12, 1360. doi: 10.3390/genes12091360.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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