R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Arg3.1 (D6H9N) Rabbit mAb #65650
Filter:
- WB
Supporting Data
| REACTIVITY | H M R |
| SENSITIVITY | Endogenous |
| MW (kDa) | 51 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
- M-Mouse
- R-Rat
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Arg3.1 (D6H9N) Rabbit mAb recognizes endogenous levels of total Arg3.1 protein. A band of unknown origin is detected ~40kDa in some rodent samples.
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val209 of human Arg3.1 protein.
Background
Arg3.1, also known as Arc for activity-regulated cytoskeleton-associated protein, is an immediate early gene whose expression is necessary for synaptic plasticity (1). Arg3.1 expression is induced by many experimental stimuli such as LTP (2), LTD (3), and learning. Arg3.1 is also involved in the regulation of synaptic strength and homeostatic scaling by promoting AMPA receptors endocytosis (5,6). Arg3.1 dysregulation has been proposed to participate in cognitive decline during aging (7).
- Guzowski, J.F. et al. (1999) Nat Neurosci 2, 1120-4.
- Lyford, G.L. et al. (1995) Neuron 14, 433-45.
- Guzowski, J.F. et al. (2000) J Neurosci 20, 3993-4001.
- Guzowski, J.F. et al. (2001) J Neurosci 21, 5089-98.
- Chowdhury, S. et al. (2006) Neuron 52, 445-59.
- Rial Verde, E.M. et al. (2006) Neuron 52, 461-74.
- Fletcher, B.R. et al. (2014) Neurobiol Learn Mem 115, 58-67.
限制使用
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For Research Use Only. Not For Use In Diagnostic Procedures.
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