R Recombinant
Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Apolipoprotein C-I (F9L6S) Rabbit mAb #92796
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 9 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
Apolipoprotein C-I (F9L6S) Rabbit mAb recognizes endogenous levels of total apolipoprotein C-I protein. This antibody detects a 35 kDa and a 45 kDa protein of unknown identity in some cell lines.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human apolipoprotein C-I protein.
Background
Apolipoprotein C-I (ApoC1) is a member of the apolipoprotein family, which takes part in the assembly of supramolecular lipoprotein complexes (1-3). The APOC1 gene is expressed in many tissues, with the highest expression in liver and differentiated macrophages (1-3). ApoC1 protein is synthesized as an 83 amino acid precursor, which is cleaved into a 57 amino acid mature protein, making it the smallest of all circulating apolipoproteins (1). ApoC1 is involved in the metabolism of triglyceride-rich lipoproteins by inhibiting the binding of very low density lipoproteins (VLDL) (4,5). ApoC1 is the main physiological inhibitor of the cholesterol ester transfer protein (CETP), which is associated with macrovascular complications in patients with type 1 diabetes (T1D) (6).
- Knott, T.J. et al. (1984) Nucleic Acids Res 12, 3909-15.
- Malmendier, C.L. et al. (1986) Atherosclerosis 62, 167-72.
- Li, W.H. et al. (1988) J Lipid Res 29, 245-71.
- Fuior, E.V. and Gafencu, A.V. (2019) Int J Mol Sci 20, 5939. doi: 10.3390/ijms20235939.
- Rouland, A. et al. (2022) Cardiovasc Diabetol 21, 272.
- Rouland, A. et al. (2024) Metabolites 14, 487. doi: 10.3390/metabo14090487.
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For Research Use Only. Not For Use In Diagnostic Procedures.
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