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CD161/KLRB1 (HP-3G10) Mouse Monoclonal Antibody (PerCP-Cy®5.5 Conjugate) #26217

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Inquiry Info. # 26217

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    Product Specifications

    REACTIVITY H
    SENSITIVITY Endogenous
    MW (kDa)
    Source/Isotype Mouse IgG1 kappa
    Application Key:
    • F-Flow Cytometry 
    Species Cross-Reactivity Key:
    • H-Human 

    Product Information

    Product Description

    This Cell Signaling Technology antibody is conjugated to PerCP-Cy5.5® and tested in-house for direct flow cytometric analysis in human cells.

    Product Usage Information

    Application Dilution
    Flow Cytometry (Live) 1:20

    Storage

    Supplied in 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH 7.2. This product is stable for 6 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze.

    实验步骤

    Specificity / Sensitivity

    CD161/KLRB1 (HP-3G10) Mouse Monoclonal Antibody (PerCP-Cy®5.5 Conjugate) recognizes endogenous levels of total CD161/KLRB1 protein. This antibody conjugate detects an epitope within the extracellular domain.

    Species Reactivity:

    Human

    Source / Purification

    This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

    Background

    CD161/KLRB1 (Killer cell lectin-like receptor subfamily B member 1, also known as CLEC5B and NKR-P1A) is a type II transmembrane protein that is expressed on the majority of Natural Killer (NK) cells, NK T cells, and some T lymphocytes (1). CD161/KLRB1 is also expressed on Th17 cells, promotes their generation, and modulates their function (2). Engagement with its ligand lectin-like transcript 1 (LLT1) inhibits NK cell function, while LLT1 and CD161/KLRB1 interaction in the presence of a TCR signal enhances IFN-gamma production by T cells (3,4). There are several different CD161 isoforms in rodents and some function as activating receptors as well (5,6).
    This HP-3G10 antibody is used for flow cytometric analysis of CD161/KLRB1 expression on NK, NKT, and various subsets of T cells.

    Alternate Names

    C-type lectin domain family 5 member B; CD161; CLEC5B; hNKR-P1A; killer cell lectin like receptor B1; Killer cell lectin-like receptor subfamily B member 1; killer cell lectin-like receptor subfamily B, member 1; KLRB1; MGC138614; Natural killer cell surface protein P1A; NKR; NKR-P1; NKR-P1A; NKRP1A; Q12918

    Database Links

    UniProt ID: Q12918


    Entrez-Gene Id: 3820


    限制使用

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    For Research Use Only. Not for Use in Diagnostic Procedures.
    Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.
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