CD1A (MTB1) Mouse mAb (#90916) Datasheet Without Images Cell Signaling Technology

For Research Use Only. Not for Use in Diagnostic Procedures.

Applications:

IHC-Bond, IHC-P

REACTIVITY:

SENSITIVITY:

Endogenous

MW (kDa):

Source/Isotype:

Mouse IgG1 kappa

UniProt ID:

#P06126

Entrez-Gene Id:

909

Product Information

Product Usage Information

Application	Dilution
IHC Leica Bond	1:50
Immunohistochemistry (Paraffin)	1:50

Storage

Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.

Specificity / Sensitivity

CD1A (MTB1) Mouse mAb recognizes endogenous levels of CD1A protein. Non-specific staining was observed in brain by immunohistochemistry.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant fusion protein corresponding to the full external domain of human CD1A protein.

Background

CD1A is a type 1 cell surface transmembrane glycoprotein structurally similar to MHC Class 1 that is expressed in association with β2-microglobulin (1). CD1A is a member of the CD1 family and has been shown to mediate the presentation of primary lipid and glycolipid antigens to T cell lymphocytes for recognition (1,2). It is expressed by Langerhans’ cells, cortical double positive and single positive thymocytes, and by interdigitating dendritic cells (1). CD1A has been shown to identify T cell development (3).

Species Reactivity

Species reactivity is determined by testing in at least one approved application (e.g., western blot).

Applications Key

IHC-Bond: IHC Leica Bond IHC-P: Immunohistochemistry (Paraffin)

Cross-Reactivity Key

H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected

Trademarks and Patents

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

SignalStain is a registered trademark of Cell Signaling Technology, Inc.

All other trademarks are the property of their respective owners. Visit cellsignal.com/trademarks for more information.

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