#P37840, #O55042
6622, 20617
| Product Includes | Quantity | Reactivity | MW(kDa) | Isotype | |
|---|---|---|---|---|---|
| Phospho-α-Synuclein (Ser129) (D1R1R) Rabbit mAb 23706 | 100 µl | H M R | 18 | Rabbit IgG | |
| α-Synuclein (D37A6) Rabbit mAb 4179 | 100 µl | M R | 18 | Rabbit IgG |
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Description
PhosphoPlus® Duets from Cell Signaling Technology (CST) provide a means to assess protein activation status. Each Duet contains an activation-state and total protein antibody to your target of interest. These antibodies have been selected from CST's product offering based upon superior performance in specified applications.
Storage
Background
α-Synuclein is a protein of 140-amino acids expressed abundantly in the brain. α-Synuclein is also the main component of pathogenic Lewy bodies and Lewy neurites. Research studies have shown that mutations of the α-Synuclein gene are linked to Parkinson's disease (1).
Various research studies have shown that phosphorylation of α-Synuclein at Ser129 is a highly toxic event that causes degeneration of dopaminergic neurons, which are associated with Parkinson's disease. This is proposed to occur through increased misfolding, aggregation, and accumulation of α-Synuclein phosphorylated at this site (2). GSK-3β is one of several kinases that has been reported to phosphorylate α-Synuclein at Ser129 (3).
Background References
Trademarks and Patents
限制使用
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