Background
AdipoRon is a small, synthetic molecule that binds both adiponectin receptors AdipoR1 and AdipoR2 with a Kd of approximately 1.8 and 3.1 mM, respectively. This synthetic adiponectin receptor agonist exhibits strong anti-obesity, anti-diabetic, anti-depressant, anti-ischemic, and anti-hypertrophic activities (1). AdipoRon behaves similarly to adiponectin in muscle and liver tissues of mice that are fed a high-fat diet, reducing insulin resistance and glucose intolerance through activation of the AMPK and PPAR-α pathways (2). Clinically, AdipoRon can be used to improve post-traumatic stress disorder, anxiety, and systemic sclerosis; it is being evaluated for the treatment of several forms of cancer, including pancreatic ductal adenocarcinoma, myeloma, breast, and ovarian cancer (3). Treatment of myeloma cell lines with AdipoRon significantly induced expression of the apoptosis-related proteins cleaved caspase-3 and cleaved PARP, and inhibited cell proliferation (4). A study using a mouse model of hypertension indicated that this AdipoRon treatment could prevent renal fibrosis in hypertensive patients (5).
- Bhat, I.A. et al. (2020) Curr Mol Pharmacol 13, 94-107.
- Okada-Iwabu, M. et al. (2013) Nature 503, 493-9.
- Nigro, E. et al. (2021) Int J Mol Sci 22, 5569. doi: 10.3390/ijms22115569.
- Wang, S.J. et al. (2020) Zhongguo Shi Yan Xue Ye Xue Za Zhi 28, 171-176.
- Li, Y. et al. (2021) J Cardiovasc Transl Res 14, 538-545.
Molecular Formula
C27H28N2O3
Molecular Weight
428.5 g/mol
Purity
>98%
CAS
924416-43-3
Solubility
Soluble in DMSO at 40 mg/mL or ethanol at 20 mg/mL.
Storage
Directions for Use
Background References
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
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