Cat. # | Size | Price | Inventory |
---|---|---|---|
12656T | 1 Kit (6 x 20 microliters) |
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Phospho-SMAD1 (Ser463/465)/ SMAD5 (Ser463/465)/ SMAD9 (Ser465/467) (D5B10) Rabbit mAb 13820 | 20 µl |
|
H M R | 60 | Rabbit IgG |
Phospho-SMAD1/5 (Ser463/465) (41D10) Rabbit mAb 9516 | 20 µl |
|
H M R | 60 | Rabbit |
Phospho-SMAD1 (Ser206) (D40B7) Rabbit mAb 5753 | 20 µl |
|
H | 60 | Rabbit IgG |
SMAD1 (D59D7) XP® Rabbit mAb 6944 | 20 µl |
|
H M Mk | 60 | Rabbit IgG |
SMAD4 (D3M6U) Rabbit mAb 38454 | 20 µl |
|
H M R Mk | 70 | Rabbit IgG |
SMAD5 (D4G2) Rabbit mAb 12534 | 20 µl |
|
H M R Mk | 60 | Rabbit IgG |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat |
Product Information
Phospho-specific monoclonal antibodies are produced by immunizing animals with synthetic phosphopeptides corresponding to residues surrounding Ser206 of human SMAD1 protein or Ser463/465 of human SMAD1 and SMAD5 proteins. Total SMAD1, SMAD4, and SMAD5 monoclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues surrounding Ser190 of human SMAD1, Asp165 of human SMAD4, or Pro249 of human SMAD5 protein.
Transforming growth factor-β (TGF-β) superfamily signaling plays a critical role in the regulation of cell growth, differentiation, and development in a wide range of biological systems. In general, signaling is initiated with ligand-induced oligomerization of serine/ threonine receptor kinases and phosphorylation of the cytoplasmic signaling molecules Smad2 and Smad3 for the TGF-β/activin pathway, or Smad1/5/9 for the bone morphogenetic protein (BMP) pathway. Carboxy-terminal phosphorylation of Smads by activated receptors results in their partnering with the common signaling transducer Smad4, and translocation to the nucleus. Activated Smads regulate diverse biological effects by partnering with transcription factors resulting in cell-state specific modulation of transcription (1-7) .
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