Cat. # | Size | Price | Inventory |
---|---|---|---|
9869T | 1 Kit (8 x 20 microliters) |
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
Cyclin A2 (BF683) Mouse mAb 4656 | 20 µl |
|
H | 55 | Mouse IgE |
Cyclin B1 Antibody 4138 | 20 µl |
|
H M R Hm Mk | 55 | Rabbit |
Cyclin D1 (92G2) Rabbit mAb 2978 | 20 µl |
|
H M R | 36 | Rabbit IgG |
Cyclin D2 (D52F9) Rabbit mAb 3741 | 20 µl |
|
H M R | 31 | Rabbit IgG |
Cyclin D3 (DCS22) Mouse mAb 2936 | 20 µl |
|
H M R | 31 | Mouse IgG1 |
Cyclin E1 (HE12) Mouse mAb 4129 | 20 µl |
|
H Mk | 48 | Mouse IgG1 |
Cyclin E2 Antibody 4132 | 20 µl |
|
H | 48 | Rabbit |
Cyclin H Antibody 2927 | 20 µl |
|
H M R | 36 | Rabbit |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat | ||
Anti-mouse IgG, HRP-linked Antibody 7076 | 100 µl |
|
Horse |
Product Information
Monoclonal antibody is produced by immunizing animals with synthetic peptides corresponding to residues within the carboxy terminus of cyclin D1, the amino terminus of cyclin D2, recombinant human cyclin E1, or cyclin A2. Polyclonal antibodies are produced by immunizing animals with synthetic peptides corresponding to residues within the carboxy terminus of cyclin H, cyclin E2, or the amino terminus of cyclin B. Polyclonal antibodies are purified by protein A and peptide affinity chromatography.
Control of the cell cycle is regulated by a multitude of cellular events and processes. The cyclin dependent kinases (CDK) regulate many of these pathways and constitute an active complex when associated with their cyclin partners. This activity is controlled primarily by phosphorylation, which determines subcellular localization of the CDK/cyclin complex (1,2). Some phosphorylation events control the function of cytoplasmic retention sequences while other events regulate nuclear localization and export sequence function (3,4). Cyclin and cyclin-dependent kinase inhibitor (CKI) levels are regulated by ubiquitination and degradation via the ubiquitin proteasome pathway (5). A variety of CKI proteins associate with these complexes and modulate access to regulatory domains on cyclins (6). Additional complexity is generated as the controlled protein levels of each cyclin oscillate with the stages of cell cycle. Increased expression of Cyclin D1 is associated with certain types of cancer (7,8) and may associate with TSC2 (tuberin) independent of its Cdk partner (9).
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