Cat. # | Size | Price | Inventory |
---|---|---|---|
78451T | 1 Kit (6 x 20 microliters) |
Product Includes | Quantity | Applications | Reactivity | MW(kDa) | Isotype |
---|---|---|---|---|---|
VEGF-A (E9X8Q) Rabbit mAb 50661 | 20 µl |
|
H | 16, 20, 23, 26 | Rabbit IgG |
VEGF Receptor 2 (D5B1) Rabbit mAb 9698 | 20 µl |
|
H M R | 210, 230 | Rabbit IgG |
Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb 2478 | 20 µl |
|
H M | 230 | Rabbit IgG |
PDGF Receptor β (28E1) Rabbit mAb 3169 | 20 µl |
|
H M R | 190 | Rabbit IgG |
Phospho-PDGF Receptor β (Tyr751) (88H8) Mouse mAb 3166 | 20 µl |
|
H M R | 190 | Mouse IgG2b |
FGF Receptor 1 (D8E4) XP® Rabbit mAb 9740 | 20 µl |
|
H M R Mk | 92 , 120, 145 | Rabbit IgG |
Phospho-FGF Receptor 1 (Tyr653/654) (D4X3D) Rabbit mAb 52928 | 20 µl |
|
H | 120, 145 | Rabbit IgG |
Phospho-Tie2 (Tyr992) Antibody 4221 | 20 µl |
|
H | 160 | Rabbit |
Anti-rabbit IgG, HRP-linked Antibody 7074 | 100 µl |
|
Goat | ||
Tie2 (D9D10) Rabbit mAb 7403 | 20 µl |
|
H | 160 | Rabbit IgG |
Product Information
Angiogenesis is defined as the physiological process by which new blood vessels are formed from pre-existing blood vessels. It is a critical process that enables specific physiological conditions in healthy adults, including development, skeletal muscle hypertrophy, and wound healing (1,2). Angiogenesis can be aberrantly activated to generate new blood vessels during pathological conditions such as cancer, neovascular disorders, and chronic inflammation. Angiogenesis is a complicated process regulated by multiple mechanisms and pathways (3). VEGFR2 is a member of the family of receptor tyrosine kinases (RTKs) mainly located in endothelial cells and is a major player in angiogenesis. VEGF-VEGFR2 ligand-receptor activation is the key signaling pathway for angiogenesis activation (4,5). Multiple non-VEGF RTK activations can replace VEGFR to promote angiogenesis (6,7), including PDGFR (9), FGFR (8), and Tie2 (10). These RTKs are targets for an antiangiogenic based disease treatment (11,12).
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