WB
H
Endogenous
19, 22
Rabbit IgG
#Q969D9
85480
Product Information
Product Usage Information
Application | Dilution |
---|---|
Western Blotting | 1:1000 |
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant human TSLP protein.
Background
TSLP (thymic stromal lymphopoietin) is a cytokine produced by epithelial cells at barrier surfaces and granulocytes (1). TSLP acts on dendritic cells, lymphocytes, and granulocytes by binding to a heterodimer composed of TSLPR (TSLP receptor) and IL-7Rα (2-5). Constitutive expression of TSLP at barrier surfaces contributes to homeostasis by promoting generation of noninflammatory dendritic cells (6). TSLP promotes the differentiation of Th2 cells and type 2 immune responses both in response to helminth infection and in the context of atopic diseases including asthma and atopic dermatitis (1,7-12).
- Soumelis, V. et al. (2002) Nat Immunol 3, 673-80.
- Reche, P.A. et al. (2001) J Immunol 167, 336-43.
- Levin, S.D. et al. (1999) J Immunol 162, 677-83.
- Park, L.S. et al. (2000) J Exp Med 192, 659-70.
- Pandey, A. et al. (2000) Nat Immunol 1, 59-64.
- Iliev, I.D. et al. (2007) J Exp Med 204, 2253-7.
- Taylor, B.C. et al. (2009) J Exp Med 206, 655-67.
- Ramalingam, T.R. et al. (2009) J Immunol 182, 6452-9.
- Ying, S. et al. (2005) J Immunol 174, 8183-90.
- Yoo, J. et al. (2005) J Exp Med 202, 541-9.
- Zhou, B. et al. (2005) Nat Immunol 6, 1047-53.
- Al-Shami, A. et al. (2005) J Exp Med 202, 829-39.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Western Blot Buffer
IMPORTANT: For western blots, incubate membrane with diluted primary antibody in 5% w/v BSA, 1X TBS, 0.1% Tween® 20 at 4°C with gentle shaking, overnight.
Applications Key
WB: Western Blotting
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
限制使用
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