| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| Tuberin/TSC2 (D93F12) XP® Rabbit mAb | 4308 | 20 µl | 200 kDa | Rabbit IgG |
| Phospho-Tuberin/TSC2 (Ser939) Antibody | 3615 | 20 µl | 200 kDa | Rabbit |
| Phospho-Tuberin/TSC2 (Thr1462) (5B12) Rabbit mAb | 3617 | 20 µl | 200 kDa | Rabbit IgG |
| Phospho-Tuberin/TSC2 (Ser1387) Antibody | 5584 | 20 µl | 200 kDa | Rabbit |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Phospho-TSC2 Antibody Sampler Kit provides an economical means to investigate protein folding within the cell. The kit contains enough primary and secondary antibodies to perform two western blot experiments per primary antibody.
Storage
Background
Tuberin is a product of the TSC2 tumor suppressor gene and an important regulator of cell proliferation and tumor development (1). Mutations in either TSC2 or the related TSC1 (hamartin) gene cause tuberous sclerosis complex (TSC), an autosomal dominant disorder characterized by development of multiple, widespread non-malignant tumors (2). Tuberin is directly phosphorylated at Thr1462 by Akt/PKB (3). Phosphorylation at Thr1462 and Tyr1571 regulates tuberin-hamartin complexes and tuberin activity (3-5). In addition, tuberin inhibits the mammalian target of rapamycin (mTOR), which promotes inhibition of p70 S6 kinase, activation of eukaryotic initiation factor 4E binding protein 1 (4E-BP1, an inhibitor of translation initiation), and eventual inhibition of translation (3,6,7).
- Soucek, T. et al. (1998) Proc Natl Acad Sci U S A 95, 15653-8.
- Sparagana, S.P. and Roach, E.S. (2000) Curr Opin Neurol 13, 115-9.
- Manning, B.D. et al. (2002) Mol Cell 10, 151-62.
- Aicher, L.D. et al. (2001) J Biol Chem 276, 21017-21.
- Dan, H.C. et al. (2002) J Biol Chem 277, 35364-70.
- Goncharova, E.A. et al. (2002) J Biol Chem 277, 30958-67.
- Inoki, K. et al. (2002) Nat Cell Biol 4, 648-57.
Background References
Trademarks and Patents
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