| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| E-Cadherin (24E10) Rabbit mAb | 3195 | 20 µl | 135 kDa | Rabbit IgG |
| p53 (7F5) Rabbit mAb | 2527 | 20 µl | 53 kDa | Rabbit IgG |
| Stathmin Antibody | 3352 | 20 µl | 19 kDa | Rabbit |
| BRCA1 Antibody | 9010 | 20 µl | 220 kDa | Rabbit |
| Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb | 4060 | 20 µl | 60 kDa | Rabbit IgG |
| PTEN (138G6) Rabbit mAb | 9559 | 20 µl | 54 kDa | Rabbit IgG |
| Phospho-Estrogen Receptor α (Ser167) (D1A3) Rabbit mAb | 5587 | 20 µl | 66 kDa | Rabbit IgG |
| HER2/ErbB2 (D8F12) XP® Rabbit mAb | 4290 | 20 µl | 185 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Oncogenes and Tumor Suppressor Antibody Sampler Kit offers an economical means of investigating proteins commonly involved in the biological pathways behind oncogenesis, tumor metastasis, and cancer pathology. The kit contains enough primary and secondary antibody to perform four western blot experiments with each antibody.
Storage
Background
Oncogenesis is a multistep process leading to sequential alterations in several oncogenes, tumor-suppressor genes, and microRNA genes (1,2). These alterations often disrupt the expression, function, and/or activity of proteins regulating cell growth and programmed cell death. Many of the molecular mechanisms and biological pathways driving oncogenesis and cancer pathology have been identified. The signal transduction pathways regulating apoptosis, cell-cycle progression, cell adhesion, cell migration, and DNA damage responses are often disrupted. HER2/ErbB2 (3), E-Cadherin (4), p53 (5,6), Stathmin (7), BRCA1 (8,9), Akt (10), PTEN (11), and Estrogen Receptor α (12) function in many of these pathways.
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- Peltomäki, P. (2012) Exp Cell Res 318, 299-310.
- Dittadi, R. and Gion, M. (2000) J Natl Cancer Inst 92, 1443-4.
- Hazan, R.B. et al. (2004) Ann N Y Acad Sci 1014, 155-63.
- Rahman, N. and Stratton, M.R. (1998) Annu Rev Genet 32, 95-121.
- Freed-Pastor, W.A. and Prives, C. (2012) Genes Dev 26, 1268-86.
- Belletti, B. and Baldassarre, G. (2011) Expert Opin Ther Targets 15, 1249-66.
- Gayther, S.A. et al. (1999) Am J Hum Genet 65, 1021-9.
- Scully, R. and Livingston, D.M. (2000) Nature 408, 429-32.
- Jazirehi, A.R. et al. (2012) Am J Cancer Res 2, 178-91.
- Saal, L.H. et al. (2008) Nat Genet 40, 102-7.
- Pópulo, H. et al. (2012) Int J Mol Sci 13, 1886-918.
Background References
Trademarks and Patents
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