Integrin α2 Antibody

Integrin α2 Antibody recognizes endogenous levels of total integrin α2 protein.

Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly545 of human integrin α2 protein. Antibodies are purified by peptide affinity chromatography.

Integrins are α/β heterodimeric cell surface receptors that play a pivotal role in cell adhesion and migration, as well as in growth and survival (1,2). The integrin family contains at least 18 α and 8 β subunits that form 24 known integrins with distinct tissue distribution and overlapping ligand specificities (3). Integrins not only transmit signals to cells in response to the extracellular environment (outside-in signaling), but also sense intracellular cues to alter their interaction with the extracellular environment (inside-out signaling) (1,2).
Integrin alpha-2, also known as cluster of differentiation 49b, forms a heterodimer with integrin beta-1. This integral membrane receptor complex interacts with extracellular matrix molecules laminin, collagen, collagen C-propeptides, fibronectin, and E-cadherin (3-6). It can also act as a receptor for viral pathogens (7,8). Integrin alpha-2/beta-1 is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, and force generation and organization of newly synthesized extracellular matrix (3).