WB, IHC-P
H M R
Endogenous
15
Rabbit IgG
#Q01469
2171
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Human, Mouse, Rat
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human FABP5 protein.
Background
Fatty acid binding proteins (FABPs) bind to fatty acids and other lipids to function as cytoplasmic lipid chaperones (1). They participate in the transport of fatty acids and other lipids to various cellular pathways (1). They are critical mediators of metabolic processes, and are increasingly being understood to play key roles in disease (2). FABP5 is known as the epidermal fatty acid binding protein as it was originally identified in studies on psoriasis (3) where it was shown to play a role a role in keratinocyte differentiation (4). It has since been found to play diverse roles in other normal physiological processes as well as in disease states (5).
- Haunerland, N.H. and Spener, F. (2004) Prog Lipid Res 43, 328-49.
- Hotamisligil, G.S. and Bernlohr, D.A. (2015) Nat Rev Endocrinol 11, 592-605.
- Madsen, P. et al. (1992) J Invest Dermatol 99, 299-305.
- Siegenthaler, G. et al. (1994) Biochem J 302 ( Pt 2), 363-71.
- Thumser, A.E. et al. (2014) Curr Opin Clin Nutr Metab Care 17, 124-9.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
WB: Western Blotting IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
限制使用
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