| Product Includes | Product # | Quantity | Mol. Wt | Isotype/Source |
|---|---|---|---|---|
| Myelin Basic Protein (E9P7U) Mouse mAb | 83683 | 20 µl | 12-18 kDa | Mouse IgG2b kappa |
| PLP1 (E9V1N) Rabbit mAb | 28702 | 20 µl | 20-30 kDa | Rabbit IgG |
| MOG (E5K6T) XP® Rabbit mAb | 96457 | 20 µl | 46, 35, 28, 23 kDa | Rabbit IgG |
| MAG (D4G3) XP® Rabbit mAb | 9043 | 20 µl | 100 kDa | Rabbit IgG |
| Caspr (D8I3V) Rabbit mAb | 97736 | 20 µl | 190 kDa | Rabbit IgG |
| Caspr2 (D6S1O) Rabbit mAb | 61962 | 20 µl | 150 kDa | Rabbit IgG |
| Neurofascin 155 (D7B6O) Rabbit mAb | 15035 | 20 µl | 140-155 kDa | Rabbit IgG |
| Neurofascin 186 (D6G6O) Rabbit mAb | 15034 | 20 µl | 200 kDa | Rabbit IgG |
| β3-Tubulin (D71G9) XP® Rabbit mAb | 5568 | 20 µl | 55 kDa | Rabbit IgG |
| Anti-rabbit IgG, HRP-linked Antibody | 7074 | 100 µl | Goat |
Please visit cellsignal.com for individual component applications, species cross-reactivity, dilutions, protocols, and additional product information.
Description
The Demyelinating Disease Targets Antibody Sampler Kit provides an economical means of detecting the protein components of myelin sheath. The kit includes enough antibodies to perform two western blot experiments with each primary antibody.
Storage
Background
Myelin is the insulating material surrounding neuronal axons. The function of myelin is to promote action potential propagation down the axon to the axon terminal. Myelin is formed in the central nervous system (CNS) by specialized glial cells called oligodendrocytes and by Schwann cells in the peripheral nervous system (PNS). Oligodendrocytes and Schwann cells make concentric rings, called the myelin sheath, around the axon at regular intervals. These intervals, called nodes of ranvier, are enriched in structural proteins and ion channels, which help promote action potential propagation. Several proteins are enriched in the myelin sheath and likely help mediate the tight multi-layered membranes that make up the sheath. These proteins include myelin basic protein (MBP, [1]), myelin-associated glycoprotein (MAG, [2]), myelin proteolipid protein (PLP1, [3]) and myelin-oligodendrocyte glycoprotein (MOG, [4]). Contactin-associated protein (Caspr) 1 & 2 (5,6) and neurofascin 155 & 186 (7,8) are nodes of ranvier-associated proteins that may play roles in generating the regular intervals of myelin along the axon. Expression of several of these proteins are altered in demyelinating diseases such as multiple sclerosis (MS). Additionally, mislocalization and/or altered expression of these proteins, compared to the axonal protein β3-tubulin, may represent altered myelin function.
- Harauz, G. and Boggs, J.M. (2013) J Neurochem 125, 334-61.
- Li, M. et al. (1996) J Neurosci Res 46, 404-14.
- Thomson, C.E. et al. Dev Neurosci 27, 27-36.
- Johns, T.G. and Bernard, C.C. (1999) J Neurochem 72, 1-9.
- Rios, J.C. et al. (2000) J Neurosci 20, 8354-64.
- Einheber, S. et al. (1997) J Cell Biol 139, 1495-506.
- Charles, P. et al. (2002) Curr Biol 12, 217-20.
- Thaxton, C. et al. (2011) Neuron 69, 244-57.
Background References
Trademarks and Patents
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