IHC-P
H
Endogenous
Rabbit IgG
#P06734
2208
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
Storage
Specificity / Sensitivity
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala118 of human CD23 protein.
Background
CD23, also known as FcεRII, is a trimeric type II transmembrane glycoprotein member of the calcium-dependent (C-type) lectin family (1). CD23 is expressed in B and T lymphocytes, monocytes, polymorphonuclear leukocytes, follicular dendritic cells, intestinal epithelial cells, and bone marrow stromal cells (2-8). CD23 was first identified as a low-affinity receptor for IgE and the engagement of membrane bound CD23 leads to suppressed IgE production by B lymphocytes (9). CD23 can be cleaved to form a soluble protein which can drive cytokine release in monocytic cells, nitric oxide (NO) production, and the synthesis of cyclic adenosine 3′5′-monophosphate (cAMP) (10). Soluble CD23 signals through integrins, activating MAPK and NF-κB pathways (11). CD23 is a useful marker in the prognosis of neoplastic disease, is elevated in a variety of autoimmune and inflammatory conditions, and is being investigated as a therapeutic target for IgE-mediated allergy, arthritis, and B cell chronic lymphocytic leukemia (CLL) (12).
- Wurzburg, B.A. et al. (2006) Structure 14, 1049-58.
- Armitage, R.J. et al. (1989) Eur J Immunol 19, 31-5.
- Vercelli, D. et al. (1988) J Exp Med 167, 1406-16.
- Yamaoka, K.A. et al. (1996) Int Immunol 8, 479-90.
- Capron, M. et al. (1992) Immunol Res 11, 252-9.
- Rieber, E.P. et al. (1993) Adv Exp Med Biol 329, 393-8.
- Yu, L.C. et al. (2003) Am J Physiol Gastrointest Liver Physiol 285, G223-34.
- Fourcade, C. et al. (1992) Eur Cytokine Netw 3, 539-43.
- Suter, U. et al. (1987) Nucleic Acids Res 15, 7295-308.
- Rezzonico, R. et al. (2001) Blood 97, 2932-40.
- Rezzonico, R. et al. (2000) Blood 95, 3868-77.
- Acharya, M. et al. (2010) Clin Exp Immunol 162, 12-23.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
限制使用
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