WB, IHC-P
H M
Endogenous
10
Rabbit IgG
#P13501
6352
Product Information
Product Usage Information
This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN, or CUT&Tag assays. If you require a carrier-free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.
Formulation
For standard formulation of this product see product #36467.
Storage
Specificity / Sensitivity
Species Reactivity:
Human, Mouse
Source / Purification
Monoclonal antibody is produced by immunizing animals with human CCL5/RANTES recombinant protein.
Background
RANTES/CCL5 (regulated upon activation, T cell expressed and secreted) is a member of the "C-C" or β family of chemokines that induce inflammation and are associated with a number of inflammatory disorders (1,2). RANTES is produced and secreted mainly by CD8+ T cells, macrophages, and platelets, as well as epithelial cells, fibroblasts, and some solid tumors (2-7). RANTES acts as a chemoattractant and has other regulatory functions on a number of cell types, including monocytes, memory T cells, NK cells, eosinophils, basophils, dendritic cells, and mast cells (3, 7-9). Signaling by RANTES is mediated by several G protein-coupled receptors (GPCRs), including CCR1, CCR3, CCR4, and CCR5.
- Schall, T.J. (1991) Cytokine 3, 165-83.
- Schall, T.J. et al. (1988) J Immunol 141, 1018-25.
- Kameyoshi, Y. et al. (1992) J Exp Med 176, 587-92.
- Rathanaswami, P. et al. (1993) J Biol Chem 268, 5834-9.
- Mattei, S. et al. (1994) Int J Cancer 56, 853-7.
- Stellato, C. et al. (1995) J Immunol 155, 410-8.
- Schall, T.J. et al. (1990) Nature 347, 669-71.
- Kuna, P. et al. (1992) J Immunol 149, 636-42.
- Mattoli, S. et al. (1995) Biochem Biophys Res Commun 209, 316-21.
Species Reactivity
Species reactivity is determined by testing in at least one approved application (e.g., western blot).
Applications Key
WB: Western Blotting IHC-P: Immunohistochemistry (Paraffin)
Cross-Reactivity Key
H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected
Trademarks and Patents
限制使用
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