CA 19-9 (C241:5:1:4) Mouse mAb (#68030) Datasheet with Images Cell Signaling Technology

For Research Use Only. Not for Use in Diagnostic Procedures.

Applications:

IHC-Bond, IHC-P

REACTIVITY:

SENSITIVITY:

Endogenous

MW (kDa):

Source/Isotype:

Mouse IgG1

Product Information

Product Usage Information

Application	Dilution
IHC Leica Bond	1:400 - 1:1600
Immunohistochemistry (Paraffin)	1:800 - 1:3200

Storage

Supplied in PBS containing 1% BSA and 15 mM sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.

Specificity / Sensitivity

CA 19-9 (C241:5:1:4) Mouse mAb recognizes endogenous levels of CA 19-9 protein. This antibody has minimal cross-reactivity (<1%) with sialyl lacto-N-tetraosylceramide. This antibody does not cross-react with Lewis A, Lewis B, or structurally-related substances.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with human colorectal adenocarcinoma Colo 205 cells.

Background

CA 19-9 specifically binds to the epitope of sialylated Lewis A carbohydrate structure, which is the functional ligand for E-selectin and is involved in the adhesion of cancer cells (1,2). The CA 19-9 antigen has been of clinical interest in detection, diagnosis, and management of cancers such as pancreatic and gastrointestinal carcinomas (3,4).

Species Reactivity

Species reactivity is determined by testing in at least one approved application (e.g., western blot).

Applications Key

IHC-Bond: IHC Leica Bond IHC-P: Immunohistochemistry (Paraffin)

Cross-Reactivity Key

H: human M: mouse R: rat Hm: hamster Mk: monkey Vir: virus Mi: mink C: chicken Dm: D. melanogaster X: Xenopus Z: zebrafish B: bovine Dg: dog Pg: pig Sc: S. cerevisiae Ce: C. elegans Hr: horse GP: Guinea Pig Rab: rabbit All: all species expected

Trademarks and Patents

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

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